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Drug Details

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Name:Rofecoxib
PubChem ID:5090
Pathway:Show KEGG pathways
InChI:InChI=1/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3
SMILES:CS(c1ccc(cc1)C=1COC(C1c1ccccc1)=O)(=O)=O

Properties:
Formula:C17H14O4SAtoms:22
Molecular Weight:314.356Rotatable Bonds:3
H-bond Acceptors:4H-bond Donors:0
logP:3.6385
Targets:
NameUniprot IDSourceReferencesInteraction
Arachidonate 15-lipoxygenaseLOX15_HUMANPROMISCUOUSPMID 16904331shows
Arachidonate 5-lipoxygenaseLOX5_HUMANBindingDB-shows
CaspaseICE_DROMEPROMISCUOUSPMID 14627349shows
Caspase-3CASP3_HUMANPROMISCUOUSPMID 14627349shows
CatalaseCATA_RATPROMISCUOUSPMID 17943250shows
Choline O-acetyltransferaseCLAT_RATPROMISCUOUSPMID 12654342shows
Cyclooxygenase 2Q99MH2_MOUSEPROMISCUOUSPMID 12566300shows
Cyclooxygenase 2bQ8IZA9_HUMANSuperTargetPMID 016430794shows
Cytochrome P450 1A2CP1A2_HUMANSuperCypPMID 14517190shows
Cytochrome P450 2C8CP2C8_HUMANSuperCyp-shows
Cytochrome P450 2C9CP2C9_HUMANSuperCyp-shows
Cytochrome P450 3A4CP3A4_HUMANSuperCyp-shows
ElastinELN_HUMANDrugBank-shows
Interstitial collagenaseMMP1_HUMANPROMISCUOUSPMID 16580899shows
Low-density lipoprotein receptorLDLR_MOUSEPROMISCUOUSPMID 11956125shows
Matrix metalloproteinase 2Q6GXA5_MOUSEPROMISCUOUSPMID 12566300shows
Matrix metalloproteinase 3A5GZ70_HUMANPROMISCUOUSPMID 16580899shows
Matrix metalloproteinase-9MMP9_MOUSEPROMISCUOUSPMID 12566300shows
Peroxiredoxin-6PRDX6_RATPROMISCUOUSPMID 17943250shows
Prostaglandin E synthasePTGES_HUMANPROMISCUOUSPMID 14558087shows
Prostaglandin E synthase 2PGES2_HUMANPROMISCUOUSPMID 14558087shows
Prostaglandin E synthase 3TEBP_HUMANPROMISCUOUSPMID 14558087shows
Prostaglandin G/H synthase 1PGH1_HUMANBindingDB-shows
Prostaglandin G/H synthase 1PGH1_MOUSEBindingDB-shows
Prostaglandin G/H synthase 1PGH1_RATBindingDB-shows
Prostaglandin G/H synthase 1PGH1_SHEEPBindingDB-shows
Prostaglandin G/H synthase 2PGH2_HUMANBindingDB-shows
Prostaglandin G/H synthase 2PGH2_MOUSEBindingDB-shows
Prostaglandin G/H synthase 2PGH2_RATBindingDB-shows
Prostaglandin G/H synthase 2PGH2_SHEEPBindingDB-shows
Putative cyclooxygenase-2Q6ZYK7_HUMANSuperTargetPMID 016430794shows
ReninRENI_RATPROMISCUOUSPMID 15149320shows
Stromelysin-1MMP3_HUMANPROMISCUOUSPMID 16580899shows
Tissue plasminogen activatorB8ZX62_HUMANPROMISCUOUSPMID 16580899shows
Synonyms:
162011-90-7
186912-82-3
2(5H)-Furanone, 4-(4-(methylsulfonyl)phenyl)-3-phenyl-
2(5H)-Furanone, 4-[4-(methyl-sulfonyl)phenyl]-3-phenyl-
3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one
3-Phenyl-4-(4-(methylsulfonyl)phenyl))-2(5H)-furanone
3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone
4-(4-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone
4-(4-methylsulfonylphenyl)-3-phenyl-5H-furan-2-one
4-(p-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone
4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
AC-13144
AC1L1JL6
AKOS000280931
BIDD:GT0399
Bio-0094
BRD-K21733600-001-02-6
BSPBio_002705
C07590
C116926
C17H14O4S
Cahill May Roberts brand of rofecoxib
CCG-40253
CCRIS 8967
Ceoxx
CHEBI:8887
CHEMBL122
cMAP_000024
CPD000466331
D00568
DB00533
DivK1c_006765
FT-0081390
HMS1922H11
HMS2051G16
HMS2089H20
HMS2093E04
HMS2232G21
HSDB 7262
I01-1042
Jsp003237
KBio1_001709
KBio2_000559
KBio2_002345
KBio2_003127
KBio2_004913
KBio2_005695
KBio2_007481
KBio3_002205
KBio3_002825
KBioGR_001242
KBioGR_002345
KBioSS_000559
KBioSS_002348
KS-1107
L000912
LS-70511
Merck brand of rofecoxib
Merck Frosst brand of rofecoxib
Merck Sharp & Dhome brand of rofecoxib
MK 0966
MK 0996
MK 966
MK 996
MK-0966
MK-966
MK0966
MLS000759440
MLS001165770
MLS001195623
MLS001424113
MolPort-006-817-786
MSD brand of rofecoxib
NCGC00095118-01
NCGC00095118-02
NCGC00095118-03
NCGC00095118-04
NCI60_041175
NSC720256
refecoxib
Rofecoxib
Rofecoxib (JAN/USAN/INN)
SAM001246617
SMR000466331
SPBio_000492
SpecPlus_000669
SPECTRUM1504235
Spectrum2_000446
Spectrum3_001153
Spectrum4_000631
Spectrum5_001598
Spectrum_000119
STK635144
STOCK6S-54349
UNII-0QTW8Z7MCR
Vioxx
Vioxx (TN)
Vioxx (trademark)
Vioxx Dolor
ZINC00007455
ATC-Codes:
Side-Effects:
Side-EffectFrequency
pain0.0010
extremity edema0.0010
hepatitis0.0010
thrombocytopenia0.0010
heartburn0.0010
congestive heart failure0.0010
dental pain0.0010
hallucinations0.0010
gastrointestinal bleeding0.0010
pulmonary edema0.0010
vomiting0.0010
epilepsy0.0010
toxic epidermal necrolysis0.0010
dry mouth0.0010
dyspepsia0.0010
dysmenorrhea0.0010
somnolence0.0010
hyperkalemia0.0010
cerebrovascular accident0.0010
pancytopenia0.0010
osteoarthritis0.0010
interstitial nephritis0.0010
nausea0.0010
myocardial infarction0.0010
pulmonary embolism0.0010
aseptic meningitis0.0010
lymphoma0.0010
leukopenia0.0010
chronic renal failure0.0010
acute renal failure0.0010
jaundice0.0010
stevens - johnson syndrome0.0010
gastric ulcer0.0010
hyponatremia0.0010
hypertension0.0010
dizziness0.0010
hepatic failure0.0010
urolithiasis0.0010
juvenile rheumatoid arthritis0.0010
pancreatitis0.0010
malignant neoplasm0.0010
agranulocytosis0.0010
cholecystitis0.0010
aplastic anemia0.0010
transient ischemic attack0.0010
esophageal ulcer0.0010
angina0.0010
colitis0.0010
rheumatoid arthritis0.0010
angioedema0.0010
duodenal ulcer0.0010
abdominal pain0.0010
photosensitivity0.0010
congenital anomaly0.0010
deep venous thrombosis0.0010
migraine0.0010
epigastric pain0.0010
hypersensitivity vasculitis0.0010
bronchospasm0.0010
confusion0.0010
spasm0
neuropathy0
bradycardia0
sinusitis0
paresthesia0
pelvic pain0
insomnia0
sciatica0
pharyngitis0
pneumonia0
pruritus0
venous insufficiency0
laryngitis0
blurred vision0
ulcerative stomatitis0
xerosis0
vaginitis0
vasculitis0
vertigo0
viral syndrome0
ventricular extrasystoles0
weight gain0
mouth ulceration0
urinary retention0
oral lesion0
tendinitis0
urticaria0
urinary tract infection0
upper respiratory tract infection0
arm pain0
sweating0
syncope0
tachycardia0
myalgia0
tinnitus0
tonsillitis0
joint swelling0
muscle weakness0
erythema0
chills0
abscess0
cough0
cystitis0
cyst0
tooth caries0
atopic dermatitis0
contact dermatitis0
diarrhea0
abdominal distention0
dyspnea0
dysuria0
epistaxis0
esophagitis0
rash0
constipation0
conjunctivitis0
allergic rhinitis0
alopecia0
anxiety0
arthralgia0
asthenia0
asthma0
atrial fibrillation0
back pain0
blistering0
bronchitis0
basal cell carcinoma0
cellulitis0
chest pain0
fatigue0
fever0
infection0
influenza0
bursitis0
breast lump0
menstrual disorder0
muscle cramps0
myopathy0
musculoskeletal pain0
fungal infection0
nasal congestion0
nocturia0
otitis0
otitis media0
cerumen impaction0
hypersensitivity0
flatulence0
flushing0
gastritis0
gastroenteritis0
gastroesophageal reflux0
headache0
hematochezia0
hematoma0
hemorrhoids0
diaphragmatic hernia0
herpes simplex0
herpes zoster0
hypercholesterolemia0
palpitations0