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Name:Quetiapine
PubChem ID:5002
Pathway:Show KEGG pathways
InChI:InChI=1/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2
SMILES:c1ccc2c(c1)C(=Nc1ccccc1S2)N1CCN(CC1)CCOCCO

Properties:
Formula:C21H25N3O2SAtoms:27
Molecular Weight:383.507Rotatable Bonds:6
H-bond Acceptors:4H-bond Donors:0
logP:2.1674
Targets:
NameUniprot IDSourceReferencesInteraction
5-hydroxytryptamine (Serotonin) receptor 1AQ5ZGX3_HUMANSuperTargetPMID 011277607shows
5-hydroxytryptamine (Serotonin) receptor 2AQ9P2Q9_HUMANSuperTargetPMID 011512044shows
5-hydroxytryptamine receptor 1A5HT1A_HUMANBindingDB-shows
5-hydroxytryptamine receptor 2A5HT2A_HUMANBindingDB-shows
5-hydroxytryptamine receptor 2B5HT2B_HUMANDrugBank-shows
5-hydroxytryptamine receptor 2C5HT2C_HUMANBindingDB-shows
5-hydroxytryptamine receptor 65HT6R_HUMANBindingDB-shows
Alpha-1B adrenergic receptorADA1B_HUMANDrugBank-shows
Alpha-1D adrenergic receptorADA1D_HUMANBindingDB-shows
Alpha-2C adrenergic receptorADA2C_HUMANBindingDB-shows
Cytochrome P450Q7Z448_HUMANSuperTargetPMID 010422890shows
Cytochrome P450Q86SK2_HUMANSuperTargetPMID 010422890shows
Cytochrome P450Q86SK3_HUMANSuperTargetPMID 010422890shows
Cytochrome P450 2C19CP2CJ_HUMANSuperCypPMID 15516294shows
Cytochrome P450 2D6CP2D6_HUMANSuperCypPMID 15516294shows
Cytochrome P450 3A4CP3A4_HUMANSuperTargetPMID 010422890shows
Cytochrome P450 3A5CP3A5_HUMANSuperCyp-shows
Cytochrome P450 3A7CP3A7_HUMANSuperCyp-shows
Cytochrome P450 CYP3A4Q9BZM0_HUMANSuperTargetPMID 010422890shows
Cytochrome P450 family 3 subfamily A polypeptide 4Q6GRK0_HUMANSuperTargetPMID 010422890shows
D(1A) dopamine receptorDRD1_HUMANBindingDB-shows
D(2) dopamine receptorDRD2_HUMANBindingDB-shows
D(2) dopamine receptorDRD2_RATBindingDB-shows
D(3) dopamine receptorDRD3_HUMANBindingDB-shows
D(4) dopamine receptorDRD4_HUMANBindingDB-shows
Histamine H1 receptorHRH1_HUMANBindingDB-shows
Muscarinic acetylcholine receptor M1ACM1_HUMANBindingDB-shows
Sodium-dependent serotonin transporterSC6A4_HUMANBindingDB-shows
Synonyms:
111974-69-7
111974-72-2
111974-72-2 (FUMARATE 2:1 SALT)
2-(2-(4-Dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)ethanol
2-(2-(4-DIBENZO(B,F)(1,4)THIAZEPIN-11-YL-1-PIPERAZINYL)ETHOXY)ETHANOL FUMARATE (
2-[2-(4-benzo[b][1,4]benzothiazepin-6-ylpiperazin-1-yl)ethoxy]ethanol
2-[2-(4-benzo[b][1,5]benzothiazepin-6-ylpiperazin-1-yl)ethoxy]ethanol
2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol
2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethoxy]ethanol
2-{[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethyl]oxy}ethanol
AC1L1JE6
AIDS-085406
AIDS085406
AKOS003588973
BIDD:GT0279
C07397
C21H25N3O2S
CHEBI:8707
CHEMBL716
CID5002
Co-Quetiapine
D08456
DB01224
Ethanol, 2-(2-(4-dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)-
Ethanol, 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-
HMS2093K06
HMS2231O11
HSDB 7557
I06-1980
ICI 204,636
KS-1099
L001200
LS-172170
MLS001165710
MLS001195658
NCGC00095911-01
NCGC00095911-03
NCGC00095911-04
Norsic (TN)
quetiapina
Quetiapine
Quetiapine (INN)
Quetiapine fumarate
Quetiapine hemifumarate
Quetiapine [INN:BAN]
quetiapinum
Seroquel
Seroquel (Fumarate)
SMR000550491
SPECTRUM1505187
STOCK6S-53310
UNII-BGL0JSY5SI
URKOMYMAXPYINW-UHFFFAOYSA-
ZD5077
ZINC19632628
ZM 204,636
ATC-Codes:
Side-Effects:
Side-EffectFrequency
dysarthria1.0
dyspnea1.0
sweating1.0
peripheral edema1.0
flu syndrome1.0
cough1.0
palpitation1.0
anorexia1.0
rhinitis0.185
headache0.168
pharyngitis0.15111107
dry mouth0.14600001
somnolence0.13670588
agitation0.120000005
leucopenia0.109
fatigue0.1
dizziness0.091666676
tremor0.076
constipation0.06909091
pain0.062
asthenia0.058999997
vomiting0.055000003
tachycardia0.051999997
nasal congestion0.05
postural hypotension0.04181818
dyspepsia0.041428573
weight gain0.041
abdominal pain0.040999997
anxiety0.036000002
back pain0.0325
rash0.02833333
sgot increased0.022
amblyopia0.015999999
fever0.015999999
gastroenteritis0.01111111
psychosis0.01
seborrhea0.01
pneumonia0.01
pruritus0.01
pelvic pain0.01
hemorrhoids0.01
hypoglycemia0.01
hypothyroidism0.01
impotence0.01
eye pain0.01
leg cramps0.01
leukocytosis0.01
metrorrhagia0.01
hyperlipemia0.01
orchitis0.01
hemiplegia0.01
increased salivation0.01
bone pain0.01
alkaline phosphatase increased0.01
deep thrombophlebitis0.01
malaise0.01
rectal hemorrhage0.01
dry eyes0.01
photosensitivity0.01
bradycardia0.01
lymphadenopathy0.01
abnormal gait0.01
urinary frequency0.01
tardive dyskinesia0.01
acne0.01
vaginal hemorrhage0.01
migraine0.01
mouth ulceration0.01
skin ulcer0.01
stomatitis0.01
cerebrovascular accident0.01
suicide attempt0.01
tinnitus0.01
urinary incontinence0.01
vaginitis0.01
vertigo0.01
abnormal vision0.01
vulvovaginitis0.01
weight loss0.01
urinary retention0.01
chills0.01
cerebral ischemia0.01
neck pain0.01
cystitis0.01
conjunctivitis0.01
confusion0.01
fecal incontinence0.01
flatulence0.01
pathological fracture0.01
gastritis0.01
gastroesophageal reflux0.01
vaginal moniliasis0.01
dysphagia0.01
epistaxis0.01
dyskinesia0.01
dysmenorrhea0.01
contact dermatitis0.01
dehydration0.01
ecchymosis0.01
eczema0.01
dysuria0.01
tooth caries0.01
eosinophilia0.01
moniliasis0.01
gum hemorrhage0.01
anemia0.01
hypochromic anemia0.01
hallucinations0.01
amenorrhea0.01
arthralgia0.01
arthritis0.01
asthma0.01
amnesia0.01
bundle branch block0.01
bruxism0.01
gingivitis0.01
blepharitis0.01
ataxia0.01
edema0.005499999
hypotension0.0024
hyperglycaemia0.0013461537
diabetes mellitus0.001214285
diabetic ketoacidosis0.0010
exfoliative dermatitis0.0010
agranulocytosis0.0010
thrombocytopenia0.0010
stuttering0.0010
cardiomyopathy0.0010
thrombophlebitis0.0010
av block first degree0.0010
coma0.0010
gynecomastia0.0010
choreoathetosis0.0010
atrial fibrillation0.0010
deafness0.0010
libido decreased0.0010
delirium0.0010
aphasia0.0010
angina pectoris0.0010
stevens - johnson syndrome0.0010
glaucoma0.0010
gout0.0010
nocturia0.0010
neutropenia0.0010
neuralgia0.0010
hyperthyroidism0.0010
myocarditis0.0010
melena0.0010
glossitis0.0010
glycosuria0.0010
acute kidney failure0.0010
hyponatremia0.0010
syndrome of inappropriate antidiuretic hormone0.0010
congestive heart failure0.0010
hematemesis0.0010
psoriasis0.0010
subdural hematoma0.0010
rhabdomyolysis0.0010
polyuria0.0010
hypokalemia0.0010
hiccup0.0010
drug abuse0.0010
pancreatitis0.0010
restless legs0.0010
anaphylactic reaction0.001
thinking abnormal0
disturbance in attention0
insomnia0
hypersomnia0
nervousness0
mental impairment0
elevated liver enzymes0
hypersensitivity0
angioedema0
blurred vision0
gastroenteritis viral0
heart disease0
hypertension0
manic0
hyperhidrosis0
parkinson0
neck rigidity0
urinary tract infection0
delusions0
upper respiratory tract infection0
toothache0
depersonalization0
paresthesia0
ear pain0
syncope0
seizures0
diarrhea0
euphoria0
vascular disorders0
priapism0
infection0
irritability0
emotional lability0
apathy0
chest pain0
stupor0
mediastinal disorders0
nausea0
connective tissue disorders0
nightmares0
spasm0