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Drug Details

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Name:staurosporine
PubChem ID:44299148
Pathway:Show KEGG pathways
InChI:InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1
SMILES:CN[C@@H]1CC2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O

Properties:
Formula:C28H26N4O3Atoms:35
Molecular Weight:466.531Rotatable Bonds:2
H-bond Acceptors:7H-bond Donors:2
logP:5.0737
Targets:
NameUniprot IDSourceReferencesInteraction
3-phosphoinositide-dependent protein kinase 1PDPK1_HUMANBindingDB-shows
5'-AMP-activated protein kinase catalytic subunit alpha-1AAPK1_HUMANBindingDB-shows
5'-AMP-activated protein kinase catalytic subunit alpha-2AAPK2_HUMANBindingDB-shows
Activated CDC42 kinase 1ACK1_HUMANBindingDB-shows
Activin receptor type-1ACVR1_HUMANBindingDB-shows
Activin receptor type-1BACV1B_HUMANBindingDB-shows
Alpha-type platelet-derived growth factor receptorPGFRA_HUMANBindingDB-shows
Basic fibroblast growth factor receptor 1FGFR1_HUMANBindingDB-shows
Beta-type platelet-derived growth factor receptorPGFRB_HUMANBindingDB-shows
Calcium/calmodulin-dependent protein kinase type II alpha chainKCC2A_RATBindingDB-shows
cAMP-dependent protein kinase catalytic subunit alphaKAPCA_HUMANBindingDB-shows
cAMP-dependent protein kinase catalytic subunit alphaKAPCA_RATBindingDB-shows
cAMP-dependent protein kinase catalytic subunit alphaKAPCA_MOUSEBindingDB-shows
cAMP-dependent protein kinase catalytic subunit alphaKAPCA_BOVINBindingDB-shows
cAMP-dependent protein kinase catalytic subunit betaKAPCB_HUMANBindingDB-shows
Casein kinase I isoform gamma-2KC1G2_HUMANBindingDB-shows
Casein kinase II subunit alphaCSK21_HUMANBindingDB-shows
Cell division protein kinase 2CDK2_HUMANBindingDB-shows
Cell division protein kinase 4CDK4_HUMANBindingDB-shows
Cell division protein kinase 5CDK5_HUMANBindingDB-shows
Cell division protein kinase 6CDK6_HUMANBindingDB-shows
Cell division protein kinase 7CDK7_HUMANBindingDB-shows
Cell division protein kinase 8CDK8_HUMANBindingDB-shows
Cell division protein kinase 9CDK9_HUMANBindingDB-shows
Death-associated protein kinase 1DAPK1_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 1MP2K1_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 2MP2K2_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 4MP2K4_HUMANBindingDB-shows
Dual specificity protein kinase CLK1CLK1_HUMANBindingDB-shows
Ephrin type-A receptor 2EPHA2_HUMANBindingDB-shows
Ephrin type-B receptor 1EPHB1_HUMANBindingDB-shows
Epidermal growth factor receptorEGFR_HUMANBindingDB-shows
Epidermal growth factor receptorEGFR_MOUSEBindingDB-shows
Epithelial discoidin domain-containing receptor 1DDR1_HUMANBindingDB-shows
Fibroblast growth factor receptor 2FGFR2_HUMANBindingDB-shows
Fibroblast growth factor receptor 3FGFR3_HUMANBindingDB-shows
Fibroblast growth factor receptor 4FGFR4_HUMANBindingDB-shows
FL cytokine receptorFLT3_HUMANBindingDB-shows
Focal adhesion kinase 1FAK1_HUMANBindingDB-shows
Glycogen synthase kinase-3 alphaGSK3A_HUMANBindingDB-shows
Glycogen synthase kinase-3 betaGSK3B_HUMANBindingDB-shows
Hepatocyte growth factor receptorMET_HUMANBindingDB-shows
High affinity nerve growth factor receptorNTRK1_HUMANBindingDB-shows
Inhibitor of nuclear factor kappa-B kinase subunit alphaIKKA_HUMANBindingDB-shows
Inhibitor of nuclear factor kappa-B kinase subunit betaIKKB_HUMANBindingDB-shows
Inhibitor of nuclear factor kappa-B kinase subunit epsilonIKKE_HUMANBindingDB-shows
Insulin receptorINSR_HUMANBindingDB-shows
Insulin-like growth factor 1 receptorIGF1R_HUMANBindingDB-shows
Lysyl-tRNA synthetaseSYK_HUMANBindingDB-shows
Macrophage colony-stimulating factor 1 receptorCSF1R_HUMANBindingDB-shows
MAP kinase-activated protein kinase 2MAPK2_HUMANBindingDB-shows
Mast/stem cell growth factor receptorKIT_HUMANBindingDB-shows
Mitogen-activated protein kinase 1MK01_MOUSEBindingDB-shows
Mitogen-activated protein kinase 1MK01_HUMANBindingDB-shows
Mitogen-activated protein kinase 10MK10_HUMANBindingDB-shows
Mitogen-activated protein kinase 12MK12_HUMANBindingDB-shows
Mitogen-activated protein kinase 14MK14_HUMANBindingDB-shows
Mitogen-activated protein kinase 3MK03_HUMANBindingDB-shows
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPK3CA_HUMANBindingDB-shows
Protein kinase C alpha typeKPCA_HUMANBindingDB-shows
Protein kinase C beta typeKPCB_HUMANBindingDB-shows
Protein kinase C epsilon typeKPCE_HUMANBindingDB-shows
Protein kinase C theta typeKPCT_HUMANBindingDB-shows
Protein tyrosine kinase 2 betaFAK2_HUMANBindingDB-shows
Proto-oncogene serine/threonine-protein kinase Pim-1PIM1_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase ABL1ABL1_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase FynFYN_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase LCKLCK_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase receptor retRET_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase SrcSRC_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase YesYES_HUMANBindingDB-shows
RAC-alpha serine/threonine-protein kinaseAKT1_HUMANBindingDB-shows
Receptor tyrosine-protein kinase erbB-2ERBB2_HUMANBindingDB-shows
Receptor-interacting serine/threonine-protein kinase 1RIPK1_HUMANBindingDB-shows
Rho-associated protein kinase 1ROCK1_HUMANBindingDB-shows
Ribosomal protein S6 kinase alpha-5KS6A5_HUMANBindingDB-shows
Serine/threonine-protein kinase 6STK6_HUMANBindingDB-shows
Serine/threonine-protein kinase D1KPCD1_HUMANBindingDB-shows
Serine/threonine-protein kinase PLK1PLK1_HUMANBindingDB-shows
Serine/threonine-protein kinase receptor R3ACVL1_HUMANBindingDB-shows
TGF-beta receptor type-2TGFR2_HUMANBindingDB-shows
Tubulin alpha-1A chainTBA1A_HUMANBindingDB-shows
Tyrosine-protein kinase ABL2ABL2_HUMANBindingDB-shows
Tyrosine-protein kinase BTKBTK_HUMANBindingDB-shows
Tyrosine-protein kinase CSKCSK_HUMANBindingDB-shows
Tyrosine-protein kinase HCKHCK_HUMANBindingDB-shows
Tyrosine-protein kinase ITK/TSKITK_HUMANBindingDB-shows
Tyrosine-protein kinase JAK2JAK2_HUMANBindingDB-shows
Tyrosine-protein kinase JAK3JAK3_HUMANBindingDB-shows
Tyrosine-protein kinase receptor TYRO3TYRO3_HUMANBindingDB-shows
Tyrosine-protein kinase SYKKSYK_HUMANBindingDB-shows
Tyrosine-protein kinase ZAP-70ZAP70_HUMANBindingDB-shows
Vascular endothelial growth factor receptor 1VGFR1_HUMANBindingDB-shows
Vascular endothelial growth factor receptor 2VGFR2_HUMANBindingDB-shows
Vascular endothelial growth factor receptor 3VGFR3_HUMANBindingDB-shows
Wee1-like protein kinaseWEE1_HUMANBindingDB-shows
Synonyms:
62996-74-1
C02079
CHEMBL162
GNF-PF-1389
staurosporine