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Drug Details

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Name:MEMANTINE HYDROCHLORIDE
PubChem ID:4054
Pathway:Show KEGG pathways
InChI:InChI=1/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3
SMILES:CC12CC3CC(C)(C1)CC(C3)(C2)N

Properties:
Formula:C12H21NAtoms:13
Molecular Weight:179.302Rotatable Bonds:0
H-bond Acceptors:1H-bond Donors:0
logP:3.3944
Targets:
NameUniprot IDSourceReferencesInteraction
AcetylcholinesteraseACES_RATPROMISCUOUSPMID 17188316shows
Cytochrome P450 1A1CP1A1_RATPROMISCUOUSPMID 9784030shows
Cytochrome P450 2A6CP2A6_HUMANSuperCypPMID 15378224shows
Cytochrome P450 2B6CP2B6_HUMANSuperCypPMID 15378224shows
Cytochrome P450 2C19CP2CJ_HUMANSuperCypPMID 15378224shows
Cytochrome P450 2D6CP2D6_HUMANSuperCypPMID 15378224shows
Glutamate receptor, ionotropic, N-methyl D-aspartate 1Q5VSF4_HUMANSuperTargetPMID 015901795shows
Glutamate receptor, ionotropic, N-methyl D-aspartate 1Q5VSF5_HUMANSuperTargetPMID 015901795shows
Glutamate receptor, ionotropic, N-methyl D-aspartate 1Q5VSF9_HUMANSuperTargetPMID 015901795shows
Glutamate receptor, ionotropic, N-methyl D-aspartate 2AQ547U9_HUMANSuperTargetPMID 015901795shows
Glutamate [NMDA] receptor subunit 3ANMD3A_RATPROMISCUOUSPMID 9023300shows
Glutamate [NMDA] receptor subunit 3ANMD3A_HUMANSuperTargetPMID 16533508shows
Glutamate [NMDA] receptor subunit epsilon 2 variantQ59HA9_HUMANSuperTargetPMID 011369029shows
Glutamate [NMDA] receptor subunit epsilon-1NMDE1_HUMANSuperTargetPMID 015901795shows
Glutamate [NMDA] receptor subunit epsilon-2NMDE2_HUMANSuperTargetPMID 011369029shows
Glutamate [NMDA] receptor subunit zeta-1NMDZ1_RATPROMISCUOUSPMID 9023300shows
Glutamate [NMDA] receptor subunit zeta-1NMDZ1_HUMANSuperTargetPMID 015901795shows
Metabotropic glutamate receptor 5GRM5_MOUSEPROMISCUOUSPMID 12442203shows
N-methyl-D-aspartate receptor subunit 2A variantQ59EW6_HUMANSuperTargetPMID 015901795shows
NMDA receptor 1 isoform NR1-2 variantQ59H41_HUMANSuperTargetPMID 015901795shows
NMDAR1 subunit isoform 3bQ9UPF9_HUMANSuperTargetPMID 015901795shows
NMDAR1 subunit isoform 4bQ9UPF8_HUMANSuperTargetPMID 015901795shows
Synonyms:
1,3-Dimethyl-5-adamantanamine
1-Amino-3,5-dimethyladamantane
19982-08-2
3,5-Dimethyl-1-adamantanamine
3,5-Dimethyl-1-adamantylamine
3,5-dimethyladamantan-1-amine
3,5-Dimethyladamantan-1-ylamine
3,5-dimethyladamantanylamine
3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine
3,5-dimethyltricyclo[3.3.1.1~3,7~]decan-1-amine
41100-52-1
41100-52-1 (Hydrochloride)
51052-62-1
AB00053600
AC1L1HB7
AIDS-002464
AIDS002464
AKOS000113995
BBL000737
Biomol-NT_000209
BPBio1_001117
BPBio1_001270
BSPBio_001015
C12H21N
C13736
CBMicro_020348
CCG-204092
CHEBI:152523
CHEMBL807
D-145
D08174
D145
DB01043
DivK1c_000068
DMAA
DRG-0267
Ebixa
EU-0053634
Exiba (TN)
HMS500D10
HSDB 7327
IDI1_000068
KBio1_000068
KBio2_001087
KBio2_003655
KBio2_006223
KBio3_001926
KBioGR_001543
KBioSS_001087
Lopac0_000861
LS-157051
Memantin
Memantina
Memantina [INN-Spanish]
Memantine
Memantine (INN)
Memantine HCL
MEMANTINE HYDROCHLORIDE
Memantine [INN:BAN]
Memantine [INN]
Memantinum
Memantinum [INN-Latin]
Namenda
NCGC00015705-03
NCGC00015705-04
NCGC00015705-05
NCGC00024782-02
NCGC00024782-03
NINDS_000068
Oprea1_480562
Prestwick0_000978
Prestwick1_000978
Prestwick2_000978
Prestwick3_000978
SPBio_001456
SPBio_002926
Spectrum2_001408
Spectrum3_000923
Spectrum4_001022
Spectrum5_001355
Spectrum_000607
ST057652
STK520682
Tricyclo(3.3.1.1(3,7))decan-1-amine, 3,5-dimethyl-
Tricyclo(3.3.1.13,7)decan-1-amine, 3,5-dimethyl-
UNII-W8O17SJF3T
ZERO/006024
ATC-Codes:
Side-Effects:
Side-EffectFrequency
cataract1.0
conjunctivitis1.0
transient ischemic attack1.0
pneumonia1.0
vertigo1.0
cardiac failure1.0
ataxia1.0
cerebrovascular accident1.0
syncope1.0
anemia1.0
rash0.505
dizziness0.07
headache0.06
confusion0.06
constipation0.05
hypertension0.04
coughing0.04
somnolence0.03
hallucination0.03
vomiting0.03
back pain0.03
pain0.02
dyspnea0.02
fatigue0.02
neuralgia0.01
pulmonary embolism0.01
nervousness0.01
paroniria0.01
neurosis0.01
personality disorder0.01
pulmonary edema0.01
psychosis0.01
pruritus0.01
ptosis0.01
paresthesia0.01
retinal detachment0.01
retinal hemorrhage0.01
decreased hearing0.01
sleep disorder0.01
neuropathy0.01
blurred vision0.01
parkinson0.01
esophageal ulceration0.01
eye pain0.01
urinary retention0.01
urticaria0.01
tremor0.01
tinnitus0.01
thrombophlebitis0.01
bradycardia0.01
suicide attempt0.01
skin ulceration0.01
allergic reaction0.01
myopia0.01
amnesia0.01
diverticulitis0.01
diplopia0.01
diabetes mellitus0.01
dermatitis0.01
delirium0.01
dehydration0.01
corneal opacity0.01
convulsions0.01
cerebral hemorrhage0.01
cellulitis0.01
blepharitis0.01
atrial fibrillation0.01
asthma0.01
apnea0.01
aphasia0.01
angina pectoris0.01
dysuria0.01
eczema0.01
myocardial infarction0.01
melena0.01
macula lutea degeneration0.01
leukopenia0.01
hypothermia0.01
postural hypotension0.01
hypotension0.01
hyponatremia0.01
hemorrhage0.01
hemoptysis0.01
gastroenteritis0.01
gastrointestinal hemorrhage0.01
glaucoma0.01
alopecia0.01
cardiac arrest0.01
hematuria0.01
hemiplegia0.01
thrombocytopenia0
otitis media0
tachycardia0
coma0
loss of consciousness0
acute pancreatitis0
av block0
hypoglycemia0
tardive dyskinesia0
anorexia0
dysphagia0
peripheral edema0
grand mal0
hepatitis0
cerebral infarction0
cholelithiasis0
apathy0
emotional lability0
depersonalization0
thinking abnormal0
stupor0
upper respiratory tract infection0
arthralgia0
anxiety0
sepsis0
carpal tunnel syndrome0
insomnia0
claudication0
delusions0
influenza0
acute renal failure0
organic brain syndrome0
colitis0
hepatic failure0
gastroesophageal reflux0
renal insufficiency0
chest pain0
urinary incontinence0
stevens - johnson syndrome0
urinary tract infection0
impotence0
acne0
supraventricular tachycardia0
nausea0
deep vein thrombosis0
hyperglycemia0
abnormal gait0
hyperlipidemia0
dyskinesia0
agitation0
malaise0
lymphatic disorders0
intracranial hemorrhage0
encephalopathy0
bronchitis0
diarrhea0
aspiration pneumonia0
asthenia0
gastritis0