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Drug Details

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Name:Losartan
PubChem ID:3961
Pathway:Show KEGG pathways
InChI:InChI=1/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)/f/h27H
SMILES:CCCCc1nc(c(CO)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)Cl

Properties:
Formula:C22H23ClN6OAtoms:30
Molecular Weight:422.911Rotatable Bonds:8
H-bond Acceptors:6H-bond Donors:0
logP:4.2668
Targets:
NameUniprot IDSourceReferencesInteraction
Angiotensin II receptor, type 1Q6NUP5_HUMANSuperTargetPMID 010678543shows
Angiotensin II receptor, type 1Q8TBK4_HUMANSuperTargetPMID 010678543shows
Angiotensin-converting enzymeACE_HUMANBindingDB-shows
ATGR2Q6UVH2_HUMANSuperTargetPMID 011801934shows
cAMP-specific 3',5'-cyclic phosphodiesterase 4CPDE4C_HUMANBindingDB-shows
cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNAQ53YY0_HUMANSuperTargetPMID 010678543shows
cGMP-inhibited 3',5'-cyclic phosphodiesterase APDE3A_HUMANBindingDB-shows
CYP2C9 proteinQ6IRV8_HUMANSuperTargetPMID 012743670shows
CYP2C9 proteinQ8WW80_HUMANSuperTargetPMID 012743670shows
Cytochrome P-450 2CQ9UEH3_HUMANSuperTargetPMID 012743670shows
Cytochrome P-450 2CQ9UQ59_HUMANSuperTargetPMID 012743670shows
Cytochrome P450Q7Z448_HUMANSuperTargetPMID 010877007shows
Cytochrome P450Q86SK2_HUMANSuperTargetPMID 010877007shows
Cytochrome P450Q86SK3_HUMANSuperTargetPMID 010877007shows
Cytochrome P450 1A2CP1A2_HUMANSuperCypPMID 10877007shows
Cytochrome P450 2C19CP2CJ_HUMANSuperCypPMID 10877007shows
Cytochrome P450 2C8CP2C8_HUMANSuperCyp-shows
Cytochrome P450 2C9CP2C9_HUMANSuperTargetPMID 012743670shows
Cytochrome P450 3A4CP3A4_HUMANSuperTargetPMID 010877007shows
Cytochrome P450 3A5CP3A5_HUMANSuperCypPMID 10877007shows
Cytochrome P450 CYP3A4Q9BZM0_HUMANSuperTargetPMID 010877007shows
Cytochrome P450 family 3 subfamily A polypeptide 4Q6GRK0_HUMANSuperTargetPMID 010877007shows
Cytochrome P450, family 2, subfamily C, polypeptide 9Q5VX92_HUMANSuperTargetPMID 012743670shows
Cytochrome p4502C9Q5EDC5_HUMANSuperTargetPMID 012743670shows
Type-1 angiotensin II receptorAGTR1_HUMANSuperTargetPMID 16380464shows
Synonyms:
(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol
114798-26-4
124750-99-8
1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-
1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'- biphenyl)-4-yl)methyl)-
1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (9CI)
1H-imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol
2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]imidazole-5-methanol
2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl-1H-imidazole-5-methanol
2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole
2-n-butyl-4-chloro-5-hydroxymethyl-1-[[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl]methyl]imidazole
BSPBio_002695
C07072
C22H23ClN6O
CHEBI:6541
Cozaar
DB00678
DUP 89
DuP-753
Hyzaar
KBio2_002193
KBio2_004761
KBio2_007329
KBio3_001915
KBioGR_001611
KBioSS_002193
Lortaan
Losartan
Losartan Monopotassium Salt
Losartan [INN:BAN]
LS-78746
Mixture Name
MK-954
MK954
NCGC00095125-01
NCGC00095125-02
NCGC00095125-03
Oprea1_644635
SPBio_001893
SPECTRUM1504268
Spectrum2_001677
Spectrum3_000998
Spectrum4_001126
Spectrum5_001466
Spectrum_001713
[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
ATC-Codes:
Side-Effects:
Side-EffectFrequency
cough0.21185417
urinary tract infection0.050666664
fatigue0.030750003
hypoglycemia0.030750003
back pain0.028250001
dizziness0.026666665
chest pain0.02575
infection0.0246
bronchitis0.024500001
vascular disease0.024500001
influenza0.024500001
diarrhea0.023545455
cellulitis0.022888891
asthenia0.022636365
anemia0.020299997
cataract0.015750002
hypotension0.013250001
sinusitis0.0126
knee pain0.012
leg pain0.012
gastritis0.012
muscular weakness0.010818183
pain0.01
weight gain0.009500001
fever0.0095
dyspepsia0.0095
diabetic neuropathy0.0095
hyperkalemia0.007928572
orthostatic hypotension0.0069999984
cramp0.0050
erythroderma0.0010
myositis0.0010
muscle pain0.0010
thrombocytopenia0.0010
hypertension0.0010
urticaria0.0010
nephropathy0.0010
vomiting0.0010
pruritus0.0010
eosinophilia0.0010
arthralgia0.0010
rhabdomyolysis0.0010
migraine0.0010
essential hypertension0.00092
hepatitis0.00092
anaphylactic reactions0.00092
angioedema0.00092
swelling0.00092
purpura0.00092
vasculitis0.00092
hypersensitivity0.0009
hyponatremia0.0009
tinnitus0
spasm0
pulmonary edema0
renal failure0
rhinitis0
shoulder pain0
tachycardia0
syncope0
sweating0
sialadenitis0
stevens - johnson syndrome0
toothache0
insomnia0
malaise0
memory impairment0
arm pain0
blurred vision0
photosensitivity0
neuropathy0
urinary frequency0
hyperuricemia0
joint swelling0
dry skin0
tremor0
erythema0
upper respiratory tract infection0
ventricular fibrillation0
agitation0
ventricular tachycardia0
vertigo0
dry mouth0
sinus bradycardia0
sleep disorder0
abdominal pain0
constipation0
decreased libido0
dermatitis0
somnolence0
dyspnea0
ecchymosis0
edema0
toxic epidermal necrolysis0
epistaxis0
erythema multiforme0
conjunctivitis0
confusion0
atrial fibrillation0
agranulocytosis0
alopecia0
aplastic anemia0
hemolytic anemia0
angina pectoris0
anorexia0
anxiety0
arrhythmia0
arthritis0
ataxia0
rash0
fibromyalgia syndrome0
flatulence0
interstitial nephritis0
nervousness0
nocturia0
palpitations0
pancreatitis0
panic disorder0
weakness0
paresthesia0
peripheral neuropathy0
pharyngitis0
nausea0
nasal congestion0
musculoskeletal pain0
flushing0
glycosuria0
gout0
headache0
hip pain0
hyperglycemia0
impotence0
jaundice0
leukopenia0
av block0
pneumonia0