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Name:Fluoxetine Hydrochloride
PubChem ID:3386
Pathway:Show KEGG pathways
InChI:InChI=1/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3
SMILES:CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F

Properties:
Formula:C17H18F3NOAtoms:22
Molecular Weight:309.326Rotatable Bonds:7
H-bond Acceptors:5H-bond Donors:0
logP:4.8259
Targets:
NameUniprot IDSourceReferencesInteraction
5-hydroxytryptamine receptor 2C5HT2C_HUMANSuperTargetPMID 009050900shows
AcetylcholinesteraseACES_HUMANBindingDB-shows
Amine oxidase [flavin-containing] BAOFB_HUMANSuperTargetPMID 008832583shows
CYP2C9 proteinQ6IRV8_HUMANSuperTargetPMID 011304903shows
CYP2C9 proteinQ8WW80_HUMANSuperTargetPMID 011304903shows
Cytochrome P-450 2CQ9UEH3_HUMANSuperTargetPMID 011304903shows
Cytochrome P-450 2CQ9UQ59_HUMANSuperTargetPMID 011304903shows
Cytochrome P-450 II CQ16743_HUMANSuperTargetPMID 011270912shows
Cytochrome P450Q6XP50_HUMANSuperTargetPMID 010208643shows
Cytochrome P450Q767A3_HUMANSuperTargetPMID 011270912shows
Cytochrome P450 1A2CP1A2_HUMANSuperCyp-shows
Cytochrome P450 2B6CP2B6_HUMANSuperCyp-shows
Cytochrome P450 2C19CP2CJ_HUMANSuperTargetPMID 011270912shows
Cytochrome P450 2C8CP2C8_HUMANSuperCyp-shows
Cytochrome P450 2C9CP2C9_HUMANSuperTargetPMID 011304903shows
Cytochrome P450 2D6CP2D6_HUMANSuperTargetPMID 010208643shows
Cytochrome P450 2E1CP2E1_HUMANSuperCypPMID 9298519shows
Cytochrome P450 3A4CP3A4_HUMANSuperCypPMID 11752104shows
Cytochrome P450, family 2, subfamily C, polypeptide 9Q5VX92_HUMANSuperTargetPMID 011304903shows
Cytochrome P450, family 2, subfamily D, polypeptide 6Q6NWU0_HUMANSuperTargetPMID 010208643shows
Cytochrome p4502C9Q5EDC5_HUMANSuperTargetPMID 011304903shows
Cytochrome P450db1Q16804_HUMANSuperTargetPMID 010208643shows
D(2) dopamine receptorDRD2_RATBindingDB-shows
Histamine H3 receptorHRH3_HUMANBindingDB-shows
Monoamine oxidase BQ8TBI1_HUMANSuperTargetPMID 008832583shows
Potassium voltage-gated channel subfamily H member 2KCNH2_HUMANBindingDB-shows
Sodium-dependent dopamine transporterSC6A3_HUMANBindingDB-shows
Sodium-dependent noradrenaline transporterSC6A2_HUMANBindingDB-shows
Sodium-dependent serotonin transporterSC6A4_HUMANSuperTarget-shows
Synaptic vesicular amine transporterVMAT2_HUMANSuperTargetPMID 16687477shows
Synonyms:
() or (-)-n-methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine
() or (-)-n-methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine
()-fluoxetine
()-n-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine
()-n-methyl-3-p-(p-trifluoromethylphenoxy)-3-phenylpropylamine
()-n-methyl-3-phenyl-3-[(alpha,alpha,alpha-trifluoro-p-tolyl)oxy]propylamine
()-n-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine]
()-n-methyl-gamma-[4-(trifluoromethyl)phenoxy]benzenepropanamine
(+) or
(+) or (-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine
(+) or (-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine
(+)-n-methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine
(+)-n-methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine
(+-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine
(+-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine
(+/-)-Fluoxetine
(+/-)-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine
(+/-)-N-Methyl-3-p-(p-trifluoromethylphenoxy)-3-phenylpropylamine
(+/-)-N-Methyl-3-phenyl-3-[(alpha,alpha,alpha-trifluoro-p-tolyl)oxy]propylamine
(+/-)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine]
(+/-)-N-Methyl-gamma-[4-(trifluoromethyl)phenoxy]benzenepropanamine
3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine
52341-67-0
54910-89-3
57226-07-0
59333-67-4
AB00053774
AIDS-196471
AIDS196471
Animex-On
benzenepropamine, n-methyl-gamma-(4-(trifluoromethyl)phenoxy)-, (+)-
Benzenepropamine, N-methyl-gamma-(4-(trifluoromethyl)phenoxy)-, (+-)-
Benzenepropanamine, N-methyl-.gamma.-[4-(trifluoromethyl)phenoxy]-, (.+/-.)-
benzenepropanamine, n-methyl-gamma-(4-(trifluoromethyl)phenoxy)-, (+)-
Benzenepropanamine, N-methyl-gamma-(4-(trifluoromethyl)phenoxy)-, (+-)-
benzenepropanamine, N-methyl-gamma-[4-(trifluoromethyl)phenoxy]-
benzenepropanamine, n-methyl-gamma-[4-(trifluoromethyl)phenoxy]-, ()-
Benzenepropanamine, N-methyl-gamma-[4-(trifluoromethyl)phenoxy]-, (+/-)-
Biomol-NT_000152
BPBio1_000354
BPBio1_000509
BSPBio_000461
BSPBio_003375
C17H18F3NO
CHEBI:5118
D00326
DB00472
Deprex
DivK1c_006819
dl-3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine
Eufor
Floxetine
Fluoxetin
Fluoxetina
Fluoxetina [INN-Spanish]
Fluoxetina [Spanish]
FLUOXETINE
fluoxetine (Prozac)
Fluoxetine (TN)
Fluoxetine (USAN/INN)
Fluoxetine Hcl
Fluoxetine Hydrochloride
Fluoxetine [USAN:BAN:INN]
Fluoxetine [USAN:INN:BAN]
Fluoxetinum
Fluoxetinum [INN-Latin]
Fluval
Fontex
HSDB 6633
KBio1_001763
KBio2_002159
KBio2_004727
KBio2_007295
KBio3_002595
KBioGR_001166
KBioSS_002159
Lilly-110140
Lopac0_000558
LS-31040
Methyl-[3-phenyl-3-(4-trifluoromethyl-phenoxy)-propyl]-amine
N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
N-methyl-3-phenyl-3-{[4-(trifluoromethyl)phenyl]oxy}propan-1-amine
N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine
NCGC00024879-03
NCGC00024879-04
NSC283480
Portal
Prestwick0_000511
Prestwick1_000511
Prestwick2_000511
Prestwick3_000511
Prozac
Prozac Weekly
Pulvules
SPBio_001815
SPBio_002382
SpecPlus_000723
Spectrum2_001658
Spectrum3_001648
Spectrum4_000613
Spectrum5_001518
Spectrum_001679
ST076807
TL8003595
ATC-Codes:
Side-Effects:
Side-EffectFrequency
bronchitis1.0
sexual dysfunction1.0
fatigue1.0
lightheadedness1.0
excessive sweating1.0
urinary tract infection1.0
agitation1.0
sleep disorder0.95075
tinnitus0.90571433
confusion0.88467443
hypertension0.8652273
ear pain0.8652273
amnesia0.8462223
weight gain0.8222916
urinary frequency0.8209091
chills0.5170731
chest pain0.47037497
hemorrhage0.4279437
joint pain0.3721818
vomiting0.34766945
nausea0.3160428
dysmenorrhea0.25074995
palpitation0.22443476
headache0.19987231
insomnia0.18198149
paresthesia0.16501507
rhinitis0.15288883
myalgia0.14371426
back pain0.14371422
pruritus0.14199999
dizziness0.12795742
anxiety0.12628242
asthenia0.12556128
somnolence0.12416096
nervousness0.12400008
weight loss0.11816217
abnormal vision0.10760975
tremor0.10610131
diarrhea0.07127335
anorexia0.06752272
dry mouth0.06531032
impotence0.064416654
pharyngitis0.061058793
dyspepsia0.05361536
flu syndrome0.052144714
rash0.043338027
sweating0.04024136
libido decreased0.036365833
major depressive disorder0.03333333
sinusitis0.02879999
constipation0.020285713
infection0.015380947
tooth disorder0.015
flatulence0.0148888845
peripheral edema0.012173909
abdominal pain0.0117999995
bulimia0.01177777
dyspnea0.011666666
fever0.011605256
cyst0.01
dry skin0.01
gingivitis0.01
convulsions0.01
neck pain0.01
herpes simplex0.01
flushes0.01
urticaria0.01
lymphadenopathy0.01
vaginitis0.01
eye pain0.01
neck rigidity0.01
otitis media0.01
amblyopia0.01
pneumonia0.01
suicide attempt0.009999998
dry eyes0.009999998
neurosis0.009999998
nocturia0.009999998
vertigo0.009999998
congestive heart failure0.009999998
vascular headache0.009999998
psychosis0.009999998
skin ulcer0.009999998
leg cramps0.009999998
arthritis0.009999997
glossitis0.009999997
neuropathy0.009999997
acne0.009999997
menorrhagia0.009999997
angina pectoris0.009999997
hypothyroidism0.009999997
urinary incontinence0.009999997
pelvic pain0.009999997
alopecia0.009999997
melena0.009999997
breast pain0.009999997
neuralgia0.009999997
asthma0.009999997
ataxia0.009999997
amenorrhea0.009999997
stomatitis0.009999997
aphthous stomatitis0.009999997
anemia0.009999997
abnormal gait0.009999997
hypotension0.009999997
tachycardia0.009999997
hiccup0.009999997
postural hypotension0.009999997
tenosynovitis0.009999997
syncope0.009999997
hallucinations0.009999997
dysphagia0.009999997
esophagitis0.009999997
eructation0.009999997
epistaxis0.009999997
urinary urgency0.009999997
photophobia0.009999997
cystitis0.009999997
bone pain0.009999997
dysuria0.009999997
migraine0.009999997
acute brain syndrome0.009999997
liver function tests abnormal0.009999997
urinary retention0.009999997
malaise0.009999997
gum hemorrhage0.009999997
bursitis0.009999997
gastritis0.009999997
conjunctivitis0.009999997
fibrocystic breast0.009999997
gastroenteritis0.009999997
pain0.009352937
hypokalemia0.009162788
hyperlipemia0.009162788
gout0.009162788
dehydration0.009162788
hypercholesteremia0.009162788
ecchymosis0.009162787
increased salivation0.009162787
mouth ulceration0.009162787
cholelithiasis0.009162787
colitis0.009162787
eczema0.009142855
myocardial infarct0.009142854
contact dermatitis0.009142853
polyuria0.00912195
albuminuria0.00912195
breast enlargement0.009121949
hematuria0.009121949
metrorrhagia0.009076921
vaginal hemorrhage0.008928569
hypoglycemia0.0082
personality disorder0.007911765
edema0.0059431777
arrhythmia0.0054470547
stomach ulcer0.005280484
diplopia0.0018571432
arthrosis0.0017000003
eosinophilic pneumonia0.0010
ptosis0.0010
pancytopenia0.0010
leukocytoclastic vasculitis0.0010
allergic reaction0.0010
sedimentation rate increased0.0010
pleural effusion0.0010
priapism0.0010
cataract0.0010
stevens - johnson syndrome0.0010
hepatic failure0.0010
photosensitivity0.0010
drug withdrawal0.0010
galactorrhea0.0010
urolithiasis0.0010
torticollis0.0010
urethritis0.0010
spasm0.0010
serum sickness0.0010
dyspareunia0.0010
pulmonary embolism0.0010
lung fibrosis0.0010
pyelonephritis0.0010
pyuria0.0010
kidney failure0.0010
retinal hemorrhage0.0010
salpingitis0.0010
ventricular tachycardia0.0010
hydrocephalus0.0010
moniliasis0.0010
bundle branch block0.0010
inappropriate adh secretion0.0010
jaundice0.0010
kidney calculus0.0010
bronchospasm0.0010
leukocytosis0.0010
dyskinesia0.0010
av block0.0010
abuse0.0010
carpal tunnel syndrome0.0010
hyperglycemia0.0010
exfoliative dermatitis0.0010
fungal dermatitis0.0010
hyperprolactinemia0.0010
pulmonary hypertension0.0010
hyperthyroidism0.0010
epididymitis0.0010
hepatomegaly0.0010
hyponatremia0.0010
le syndrome0.0010
serotonin syndrome0.0010
pathological fracture0.0010
numbness0.0010
optic neuritis0.0010
angioedema0.0010
hemolytic anemia0.0010
orchitis0.0010
aplastic anemia0.0010
bone necrosis0.0010
movement disorders0.0010
allergic alveolitis0.0010
gynecomastia0.0010
erythema multiforme0.0010
erythema nodosum0.0010
goitre0.0010
nystagmus0.0010
deafness0.001
diabetes mellitus0.001
enteritis0.001
abnormal electroencephalogram0.001
chondrodystrophy0.001
peripheral vascular disorder0.001
dysarthria0.001
exophthalmos0.001
duodenal ulcer0.001
liver fatty0.001
fecal incontinence0.001
diabetic acidosis0.001
cerebral ischemia0.001
alkaline phosphatase increased0.001
paralysis0.001
kidney pain0.001
atrial fibrillation0.001
atelectasis0.001
ventricular extrasystoles0.001
rheumatoid arthritis0.001
apnea0.001
hyperuricemia0.001
thrombocythemia0.001
blepharitis0.001
bradycardia0.001
cough0.001
esophageal ulcer0.001
coma0.001
iron deficiency anemia0.001
cholecystitis0.001
cerebral embolism0.001
hypoxia0.001
rectal hemorrhage0.001
hypoventilation0.001
hypochromic anemia0.001
furunculosis0.001
osteoporosis0.001
hyperacusis0.001
iritis0.001
scleritis0.001
visual field defect0.001
seborrhea0.001
hypothermia0.001
shock0.001
hypomenorrhea0.001
hypocalcemia0.001
salivary gland enlargement0.001
pneumothorax0.001
strabismus0.001
leukopenia0.001
purpura0.001
pancreatitis0.001
osteomyelitis0.001
peptic ulcer0.001
petechial rash0.001
phlebitis0.001
neuritis0.001
myositis0.001
myopathy0.001
lymphocytosis0.001
lung edema0.001
lymphedema0.001
emphysema0.001
stridor0.001
cerebrovascular accident0.001
hyperesthesia0.001
hematemesis0.001
heart block0.001
heart arrest0.001
uterine fibroids0.001
uterine hemorrhage0.001
psoriasis0.001
glycosuria0.001
ventricular fibrillation0.001
glaucoma0.001
blood dyscrasia0.001
hemoptysis0.001
gastrointestinal hemorrhage0.001
thrombophlebitis0.001
thrombocytopenia0.001
herpes zoster0.001
hepatitis0.001
hyperkalemia0.001
hirsutism0.001
euphoria0
delusions0
depersonalization0
thinking abnormal0
grand mal0
menstrual disorder0
erythema0
upper respiratory tract infection0
parkinson0
embolism0
emotional lability0
apathy0
manic0
stupor0
seizures0