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Name:Dasatinib
PubChem ID:3062316
Pathway:Show KEGG pathways
InChI:InChI=1/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)/f/h27-28H
SMILES:Cc1cccc(c1NC(c1cnc(Nc2cc(nc(C)n2)N2CCN(CC2)CCO)s1)=O)Cl

Properties:
Formula:C22H26ClN7O2SAtoms:33
Molecular Weight:488.006Rotatable Bonds:8
H-bond Acceptors:8H-bond Donors:0
logP:3.4624
Targets:
NameUniprot IDSourceReferencesInteraction
3-phosphoinositide-dependent protein kinase 1PDPK1_HUMANBindingDB-shows
5'-AMP-activated protein kinase catalytic subunit alpha-1AAPK1_HUMANBindingDB-shows
5'-AMP-activated protein kinase catalytic subunit alpha-2AAPK2_HUMANBindingDB-shows
Activated CDC42 kinase 1ACK1_HUMANBindingDB-shows
Activin receptor type-1ACVR1_HUMANBindingDB-shows
Activin receptor type-1BACV1B_HUMANBindingDB-shows
Alpha-type platelet-derived growth factor receptorPGFRA_HUMANBindingDB-shows
Basic fibroblast growth factor receptor 1FGFR1_HUMANBindingDB-shows
Beta-type platelet-derived growth factor receptorPGFRB_HUMANBindingDB-shows
cAMP-dependent protein kinase catalytic subunit alphaKAPCA_HUMANBindingDB-shows
cAMP-dependent protein kinase catalytic subunit betaKAPCB_HUMANBindingDB-shows
Casein kinase I isoform gamma-2KC1G2_HUMANBindingDB-shows
Casein kinase II subunit alphaCSK21_HUMANBindingDB-shows
Cell division protein kinase 2CDK2_HUMANBindingDB-shows
Cell division protein kinase 5CDK5_HUMANBindingDB-shows
Cell division protein kinase 7CDK7_HUMANBindingDB-shows
Cell division protein kinase 8CDK8_HUMANBindingDB-shows
Cell division protein kinase 9CDK9_HUMANBindingDB-shows
Death-associated protein kinase 1DAPK1_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 1MP2K1_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 2MP2K2_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 4MP2K4_HUMANBindingDB-shows
Dual specificity protein kinase CLK1CLK1_HUMANBindingDB-shows
Ephrin type-A receptor 2EPHA2_HUMANBindingDB-shows
Ephrin type-B receptor 1EPHB1_HUMANBindingDB-shows
Epidermal growth factor receptorEGFR_HUMANBindingDB-shows
Epithelial discoidin domain-containing receptor 1DDR1_HUMANBindingDB-shows
Fibroblast growth factor receptor 2FGFR2_HUMANBindingDB-shows
Fibroblast growth factor receptor 3FGFR3_HUMANBindingDB-shows
Fibroblast growth factor receptor 4FGFR4_HUMANBindingDB-shows
FL cytokine receptorFLT3_HUMANBindingDB-shows
Focal adhesion kinase 1FAK1_HUMANBindingDB-shows
Glycogen synthase kinase-3 alphaGSK3A_HUMANBindingDB-shows
Glycogen synthase kinase-3 betaGSK3B_HUMANBindingDB-shows
Hepatocyte growth factor receptorMET_HUMANBindingDB-shows
High affinity nerve growth factor receptorNTRK1_HUMANBindingDB-shows
Inhibitor of nuclear factor kappa-B kinase subunit alphaIKKA_HUMANBindingDB-shows
Inhibitor of nuclear factor kappa-B kinase subunit epsilonIKKE_HUMANBindingDB-shows
Insulin receptorINSR_HUMANBindingDB-shows
Insulin-like growth factor 1 receptorIGF1R_HUMANBindingDB-shows
Macrophage colony-stimulating factor 1 receptorCSF1R_HUMANBindingDB-shows
MAP kinase-activated protein kinase 2MAPK2_HUMANBindingDB-shows
Mast/stem cell growth factor receptorKIT_HUMANBindingDB-shows
Matrix metalloproteinase 9Q9Y354_HUMANPROMISCUOUSPMID 19010823shows
Mitogen-activated protein kinase 1MK01_HUMANBindingDB-shows
Mitogen-activated protein kinase 10MK10_HUMANBindingDB-shows
Mitogen-activated protein kinase 12MK12_HUMANBindingDB-shows
Mitogen-activated protein kinase 14MK14_HUMANBindingDB-shows
Mitogen-activated protein kinase 3MK03_HUMANBindingDB-shows
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPK3CA_HUMANBindingDB-shows
Protein kinase C alpha typeKPCA_HUMANBindingDB-shows
Protein kinase C beta typeKPCB_HUMANBindingDB-shows
Protein kinase C epsilon typeKPCE_HUMANBindingDB-shows
Protein kinase C theta typeKPCT_HUMANBindingDB-shows
Protein tyrosine kinase 2 betaFAK2_HUMANBindingDB-shows
Proto-oncogene serine/threonine-protein kinase Pim-1PIM1_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase ABL1ABL1_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase FynFYN_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase LCKLCK_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase receptor retRET_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase SrcSRC_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase YesYES_HUMANBindingDB-shows
RAC-alpha serine/threonine-protein kinaseAKT1_HUMANBindingDB-shows
Receptor tyrosine-protein kinase erbB-2ERBB2_HUMANBindingDB-shows
Receptor-interacting serine/threonine-protein kinase 1RIPK1_HUMANBindingDB-shows
Ribosomal protein S6 kinase alpha-5KS6A5_HUMANBindingDB-shows
Serine/threonine-protein kinase 6STK6_HUMANBindingDB-shows
Serine/threonine-protein kinase D1KPCD1_HUMANBindingDB-shows
Serine/threonine-protein kinase PLK1PLK1_HUMANBindingDB-shows
Serine/threonine-protein kinase receptor R3ACVL1_HUMANBindingDB-shows
Signal transducer and activator of transcription 5BSTA5B_HUMANDrugBank-shows
TGF-beta receptor type-2TGFR2_HUMANBindingDB-shows
Tubulin alpha-1A chainTBA1A_HUMANBindingDB-shows
Tyrosine-protein kinase ABL2ABL2_HUMANBindingDB-shows
Tyrosine-protein kinase BTKBTK_HUMANBindingDB-shows
Tyrosine-protein kinase CSKCSK_HUMANBindingDB-shows
Tyrosine-protein kinase HCKHCK_HUMANBindingDB-shows
Tyrosine-protein kinase ITK/TSKITK_HUMANBindingDB-shows
Tyrosine-protein kinase JAK2JAK2_HUMANBindingDB-shows
Tyrosine-protein kinase JAK3JAK3_HUMANBindingDB-shows
Tyrosine-protein kinase receptor TYRO3TYRO3_HUMANBindingDB-shows
Tyrosine-protein kinase SYKKSYK_HUMANBindingDB-shows
Tyrosine-protein kinase ZAP-70ZAP70_HUMANBindingDB-shows
Vascular endothelial growth factor receptor 1VGFR1_HUMANBindingDB-shows
Vascular endothelial growth factor receptor 2VGFR2_HUMANBindingDB-shows
Vascular endothelial growth factor receptor 3VGFR3_HUMANBindingDB-shows
Wee1-like protein kinaseWEE1_HUMANBindingDB-shows
Synonyms:
(18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
1N1
2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302962-49-8
5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-
BCB03_000715
BMS 354825
BMS Dasatinib
BMS-354825
BMS354825
C488369
CHEBI:49375
D03658
Dasatinib
Dasatinib (USAN)
Dasatinib [USAN]
DB01254
LS-186641
LS-187028
LS-187773
N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-MET
N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE
N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, monohydrate
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
NCGC00181129-01
nchembio.117-comp11
nchembio.162-comp4
NSC-732517
NSC732517
Sprycel
Sprycel (TN)
ATC-Codes:
Side-Effects:
Side-EffectFrequency
muscle inflammation1.0
syncope1.0
gastritis1.0
thrombophlebitis1.0
tinnitus1.0
tremor1.0
urticaria1.0
vertigo1.0
erythema nodosum1.0
convulsion1.0
renal failure1.0
nail disorder1.0
infection1.0
hypotension1.0
palpitations1.0
pancytopenia1.0
hypertension1.0
hypersensitivity1.0
pneumonitis1.0
enterocolitis1.0
somnolence1.0
colitis1.0
malaise1.0
lung infiltration1.0
asthma1.0
pigmentation disorder1.0
urinary frequency1.0
angina pectoris1.0
hyperuricemia1.0
confusional state1.0
conjunctivitis1.0
dry skin1.0
dysphagia1.0
eczema1.0
muscular weakness1.0
dermatitis1.0
dry eye1.0
neutropenia0.58166665
thrombocytopenia0.50625
anemia0.34142858
diarrhea0.14
hypophosphatemia0.117142856
pleural effusion0.10699999
hemorrhage0.0723077
edema0.067499995
nausea0.067499995
hypocalcemia0.06666666
gastrointestinal bleeding0.04
dyspnea0.036666665
vomiting0.0325
elevated sgot0.025
pyrexia0.02
fatigue0.019999998
pericardial effusion0.017499998
congestive heart failure0.015999999
pulmonary edema0.015
headache0.015
abdominal pain0.013333333
musculoskeletal pain0.013333333
amnesia0.01
skin rash0.01
arrhythmia0.01
ventricular tachycardia0.01
esophagitis0.01
acute febrile neutrophilic dermatosis0.01
photosensitivity0.01
panniculitis0.01
coagulopathy0.01
bronchospasm0.01
libido decreased0.01
transient ischemic attack0.01
menstruation irregular0.01
ulcer0.01
anal fissure0.01
tumor0.01
pericarditis0.01
myocarditis0.01
proteinuria0.01
myocardial infarction0.01
cardiomegaly0.01
acute respiratory distress syndrome0.01
rhabdomyolysis0.01
skin ulcer0.01
cerebrovascular accident0.01
gynecomastia0.01
tendonitis0.01
pancreatitis0.01
ascites0.0066666664
pulmonary hypertension0.0066666664
aplasia pure red cell0.0010
milia0
anorexia0
breast disorders0
drug eruption0
dyspepsia0
liver function tests abnormal0
tachycardia0
heart disease0
mediastinal disorders0
skin irritation0
connective tissue disorders0
erythema multiforme0
upper respiratory tract infection0
arthralgia0
myalgia0
neuropathy0
anxiety0
sepsis0
insomnia0
abdominal distention0
lupus0
hepatitis0
vascular disorders0
stomatitis0
heart failure0
chills0
herpes0
flushing0
alopecia0
pain0
chest pain0
pruritus0
acne0
cholecystitis0
cough0
hyperhidrosis0
heat rash0
leukemia0
cardiomyopathy0
constipation0
weight gain0
weight loss0
peripheral neuropathy0
viral infection0
asthenia0
dizziness0
erythema0