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Name:Iproveratril
PubChem ID:2520
Pathway:Show KEGG pathways
InChI:InChI=1/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3
SMILES:CC(C)C(CCCN(C)CCc1ccc(c(c1)OC)OC)(C#N)c1ccc(c(c1)OC)OC

Properties:
Formula:C27H38N2O4Atoms:33
Molecular Weight:454.602Rotatable Bonds:13
H-bond Acceptors:6H-bond Donors:0
logP:5.09308
Targets:
NameUniprot IDSourceReferencesInteraction
ATP-sensitive inward rectifier potassium channel 11IRK11_HUMANDrugBank-shows
Canalicular multispecific organic anion transporter 1MRP2_HUMANBindingDB-shows
Carbonic anhydrase 1CAH1_HUMANDrugBank-shows
Cytochrome P450Q7Z448_HUMANSuperTargetPMID 011724091shows
Cytochrome P450Q86SK2_HUMANSuperTargetPMID 011724091shows
Cytochrome P450Q86SK3_HUMANSuperTargetPMID 011724091shows
Cytochrome P450 1A2CP1A2_HUMANSuperCypPMID 8232610shows
Cytochrome P450 2B6CP2B6_HUMANSuperCypPMID 10461547shows
Cytochrome P450 2C19CP2CJ_HUMANSuperCypPMID 8750925shows
Cytochrome P450 2C8CP2C8_HUMANSuperTargetPMID 012972955shows
Cytochrome P450 2C9CP2C9_HUMANSuperCypPMID 10640508shows
Cytochrome P450 2D6CP2D6_HUMANSuperCypPMID 10640508shows
Cytochrome P450 3A4CP3A4_HUMANBindingDB-shows
Cytochrome P450 3A5CP3A5_HUMANSuperCyp-shows
Cytochrome P450 3A7CP3A7_HUMANSuperCyp-shows
Cytochrome P450 CYP3A4Q9BZM0_HUMANSuperTargetPMID 011724091shows
Cytochrome P450 family 3 subfamily A polypeptide 4Q6GRK0_HUMANSuperTargetPMID 011724091shows
Multidrug resistance protein 1MDR1_HUMANBindingDB-shows
Multidrug resistance protein 1 variantQ59GY9_HUMANSuperTargetPMID 016339857shows
P-glycoproteinO60213_HUMANSuperTargetPMID 016339857shows
P-glycoprotein 1Q6TBL4_HUMANSuperTargetPMID 016339857shows
Potassium voltage-gated channel subfamily H member 2KCNH2_HUMANBindingDB-shows
Sodium channel protein type 5 subunit alphaSCN5A_HUMANDrugBank-shows
Voltage-dependent calcium channel gamma-1 subunitCCG1_HUMANDrugBank-shows
Voltage-dependent L-type calcium channel subunit alpha-1CCAC1C_HUMANBindingDB-shows
Voltage-dependent L-type calcium channel subunit alpha-1DCAC1D_HUMANDrugBank-shows
Voltage-dependent L-type calcium channel subunit alpha-1FCAC1F_HUMANDrugBank-shows
Voltage-dependent L-type calcium channel subunit alpha-1SCAC1S_HUMANDrugBank-shows
Voltage-dependent L-type calcium channel subunit beta-1CACB1_HUMANDrugBank-shows
Voltage-dependent L-type calcium channel subunit beta-2CACB2_HUMANDrugBank-shows
Voltage-dependent L-type calcium channel subunit beta-3CACB3_HUMANDrugBank-shows
Voltage-dependent L-type calcium channel subunit beta-4CACB4_HUMANDrugBank-shows
Voltage-dependent T-type calcium channel subunit alpha-1GCAC1G_HUMANDrugBank-shows
Voltage-dependent T-type calcium channel subunit alpha-1ICAC1I_HUMANDrugBank-shows
Synonyms:
(+)-verapamil
(+-)-Verapamil
(1)-3-(3,4-Dimethoxyphenyl)-6-((5,6-dimethoxyphenethyl)methylamino)hexane-3-carbonitrile
152-11-4 (HYDROCHLORIDE SALT)
2-(3,4-Dimethoxyphenyl)-5-((2-(3,4-dimethoxyphenyl)ethyl)(methyl)amino)-2-isopropylpentanenitrile, (+/-)-
2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-(1-methylethyl) pentanenitrile
2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropy
5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
52-53-9
52-53-9 (FREE BASE)
56949-77-0
AB00053495
AIDS-002990
AIDS002990
alpha-((N-Methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile
alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)-methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile
alpha-Isopropyl-alpha-((N-methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile
Benzeneacetonitrile, .alpha.-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-.alpha.-(1-methylethyl)-
Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino) propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-
Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-
Bio1_000425
Bio1_000914
Bio1_001403
Bio2_000233
Bio2_000713
BPBio1_000268
BSPBio_000242
BSPBio_001513
BSPBio_002358
C07188
C27H38N2O4
Calan
Calcan
Cardibeltin
CCRIS 6749
CHEBI:9948
cMAP_000023
Cordilox
Covera-HS
CP-16533-1
D-365
D02356
DB00661
Dexverapamil
Dilacoran
DivK1c_000399
EINECS 200-145-1
EINECS 260-462-6
Falicard
Finoptin
IDI1_000399
IDI1_033983
Iproveratril
Isoptimo
Isoptin
Isoptine
Isotopin
Izoptin
KBio1_000399
KBio2_000233
KBio2_002343
KBio2_002801
KBio2_004911
KBio2_005369
KBio2_007479
KBio3_000465
KBio3_000466
KBio3_002823
KBioGR_000233
KBioGR_001372
KBioGR_002343
KBioSS_000233
KBioSS_002346
Lopac0_001237
LS-174
Manidon
NCGC00024710-04
NCGC00024710-05
NCGC00024710-06
NCGC00024710-07
NCGC00024710-08
NCGC00024710-09
nchembio.79-comp5
NCI60_020143
NINDS_000399
NSC 135784
NSC272366 (HYDROCHLORIDE SALT)
NSC657799 (HYDROCHLORIDE SALT)
Prestwick0_000141
Prestwick1_000141
Prestwick2_000141
Prestwick3_000141
SPBio_001820
SPBio_002181
Spectrum2_001740
Spectrum4_000906
Spectrum5_001786
STOCK2S-60963
Valeronitrile, 5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropyl-
Vasolan
Verapamil
Verapamil (USAN/INN)
Verapamil HCl
Verapamil hydrochloride
Verapamil [USAN:BAN:INN]
Verapamil [USAN:INN:BAN]
Verapamilo
Verapamilo [INN-Spanish]
Verapamilum
Verapamilum [INN-Latin]
Verelan
ATC-Codes:
Side-Effects:
Side-EffectFrequency
infection0.08866667
constipation0.062083334
upper respiratory infection0.054
headache0.03883334
flu syndrome0.03375
peripheral edema0.03275
dizziness0.030919995
rhinitis0.027
sinusitis0.02675
pharyngitis0.02675
dyspepsia0.024666667
pain0.024
diarrhea0.024
nausea0.0226
hypotension0.020352943
fatigue0.02021429
asthenia0.02
ecg abnormal0.02
edema0.017708331
pulmonary edema0.017000003
hypertension0.017
rash0.014333334
elevated liver enzymes0.014
dyspnea0.014
ankle edema0.014
bradycardia0.0139999995
av block0.011777779
myalgia0.011
paresthesia0.01
flushing0.0064000003
postural hypotension0.0040
paralysis0.0010
gynecomastia0
sweating0
palpitations0
ecchymosis0
muscle cramps0
urinary frequency0
heart failure0
bronchospasm0
cardiomyopathy0
vasculitis0
allergic reaction0
hepatitis0
somnolence0
erythema multiforme0
depressive symptoms0
hyperkeratosis0
increased sweating0
arthralgia0
oligomenorrhea0
insomnia0
abnormal vision0
vomiting0
ihss0
respiratory failure0
angioedema0
galactorrhea0
tremor0
anaphylaxis0
claudication0
chest pain0
jaundice0
paralytic ileus0
dry mouth0
urticaria0
pruritus0
muscle weakness0
stevens - johnson syndrome0
confusion0
myocardial infarction0
sinus arrest0
syncope0
alopecia0
cerebrovascular accident0
spasm0
seizures0
nystagmus0
tinnitus0
vertigo0
impotence0
hypersensitivity0
hyperprolactinemia0
purpura0
blurred vision0
numbness0
diplopia0