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Drug Details

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Name:Astemizole
PubChem ID:2247
Pathway:Show KEGG pathways
InChI:InChI=1/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31)/f/h30H
SMILES:COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2ccccc2n1Cc1ccc(cc1)F

Properties:
Formula:C28H31FN4OAtoms:34
Molecular Weight:458.57Rotatable Bonds:8
H-bond Acceptors:5H-bond Donors:0
logP:5.3622
Targets:
NameUniprot IDSourceReferencesInteraction
Cytochrome P450Q6XP50_HUMANSuperTargetPMID 010597902shows
Cytochrome P450Q7Z448_HUMANSuperTargetPMID 009649346shows
Cytochrome P450Q86SK2_HUMANSuperTargetPMID 009649346shows
Cytochrome P450Q86SK3_HUMANSuperTargetPMID 009649346shows
Cytochrome P450 2D6CP2D6_HUMANSuperTargetPMID 010597902shows
Cytochrome P450 2J2CP2J2_HUMANSuperCypPMID 12386130shows
Cytochrome P450 3A4CP3A4_HUMANSuperTargetPMID 009649346shows
Cytochrome P450 3A5CP3A5_HUMANSuperCyp-shows
Cytochrome P450 3A7CP3A7_HUMANSuperCyp-shows
Cytochrome P450 CYP3A4Q9BZM0_HUMANSuperTargetPMID 009649346shows
Cytochrome P450 family 3 subfamily A polypeptide 4Q6GRK0_HUMANSuperTargetPMID 009649346shows
Cytochrome P450, family 2, subfamily D, polypeptide 6Q6NWU0_HUMANSuperTargetPMID 010597902shows
Cytochrome P450db1Q16804_HUMANSuperTargetPMID 010597902shows
Histamine H1 receptorHRH1_HUMANSuperTargetPMID 010597864shows
Multidrug resistance protein 1MDR1_HUMANBindingDB-shows
Potassium channel HERGQ6U279_HUMANSuperTargetPMID 011575008shows
Potassium channel HERGQ6U283_HUMANSuperTargetPMID 011575008shows
Potassium channel HERGQ6U287_HUMANSuperTargetPMID 011575008shows
Potassium channel HERG1Q45QN5_HUMANSuperTargetPMID 011575008shows
Potassium voltage-gated channel subfamily H member 2KCNH2_HUMANSuperTargetPMID 011575008shows
Potassium voltage-gated channel, subfamily H (Eag-related), member 2Q708S9_HUMANSuperTargetPMID 011575008shows
Potassium voltage-gated channel, subfamily H (Eag-related), member 2Q86U57_HUMANSuperTargetPMID 011575008shows
Putative uncharacterized protein KCNH2Q75MK8_HUMANSuperTargetPMID 011575008shows
Putative uncharacterized protein KCNH2Q75MK9_HUMANSuperTargetPMID 011575008shows
Somatostatin receptor type 2SSR2_HUMANBindingDB-shows
Somatostatin receptor type 5SSR5_HUMANBindingDB-shows
Voltage-gated potassium channelQ45QN4_HUMANSuperTargetPMID 011575008shows
Synonyms:
1-((4-Fluorophenyl)methyl)-N-(1-(2-(4-methoxyphenyl)ethyl)-4-piperidinyl)- 1H-benzimidazol-2-amine
1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole
1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidaz
1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole
1-[(4-fluorophenyl)methyl]-N-(1-{2-[4-(methyloxy)phenyl]ethyl}piperidin-4-yl)-1H-benzimidazol-2-amine
1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine
1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl]benzimidazol-2-amine
1-[(fluorophenyl)-methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine
1H-Benzimidazol-2-amine, 1-((4-fluorophenyl)methyl)-N-(1-(2-(4-methoxyphenyl)eth l)-4-piperidinyl)-
1H-Benzimidazol-2-amine, 1-((4-fluorophenyl)methyl)-N-(1-(2-(4-methoxyphenyl)ethyl)-4-piperidinyl)-
1H-Benzimidazol-2-amine, 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-
1H-Benzimidazol-2-amine,1-((4-fluorophenyl)methyl)-N-(1-(2-(4-methoxyphenyl)ethyl)-4-piperdinyl)
68844-77-9
AB00052413
Alermizol
Astemison
Astemizol
Astemizol [German]
Astemizol [INN-Spanish]
Astemizole
Astemizole (JAN/USP/INN)
Astemizole [USAN:BAN:INN]
Astemizolum
Astemizolum [INN-Latin]
Benzimidazole, 1-(p-fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)-
BPBio1_000234
BRN 4830190
BSPBio_000212
BSPBio_002684
C06832
C28H31FN4O
CAS-68844-77-9
CCRIS 7595
CHEBI:2896
D00234
DB00637
DivK1c_000039
EINECS 272-441-9
Hestazol
Hestazol, Kelp, Laridal, Retolen, Wareezol, HSBD 6799, BRN 4830190
Hismanal
Hismanal (TN)
Histamen
Histaminos
HSDB 6799
IDI1_000039
KBio1_000039
KBio2_000928
KBio2_003496
KBio2_006064
KBio3_001904
KBioGR_001686
KBioSS_000928
Kelp
Laridal
LS-32978
Metodih
MJD-30
MLS000028667
MLS001148073
NCGC00016913-01
NCGC00018288-01
NCGC00022520-03
NCGC00022520-04
NCGC00022520-05
NCGC00022520-06
NCGC00022520-07
nchembio732-comp2
nchembio806-comp1
NINDS_000039
Novo-mastizol A
NSC329963
Paralergin
Prestwick0_000136
Prestwick1_000136
Prestwick2_000136
Prestwick3_000136
Prestwick_35
QTL1_000010
R 42512
R-43-512
R-43512
Retolen
SMR000058911
SPBio_001804
SPBio_002151
SPECTRUM2300094
Spectrum2_001732
Spectrum3_001072
Spectrum4_001223
Spectrum5_001239
Spectrum_000448
UPCMLD-DP024
UPCMLD-DP024:001
Wareezol
[3H]Astemizole
ATC-Codes: