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Name:sorafenibum
PubChem ID:216239
Pathway:Show KEGG pathways
InChI:InChI=1/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)/f/h26,28-29H
SMILES:CNC(c1cc(ccn1)Oc1ccc(cc1)NC(Nc1ccc(c(c1)C(F)(F)F)Cl)=O)=O

Properties:
Formula:C21H16ClF3N4O3Atoms:32
Molecular Weight:464.825Rotatable Bonds:9
H-bond Acceptors:10H-bond Donors:0
logP:6.0866
Targets:
NameUniprot IDSourceReferencesInteraction
3-phosphoinositide-dependent protein kinase 1PDPK1_HUMANBindingDB-shows
5'-AMP-activated protein kinase catalytic subunit alpha-1AAPK1_HUMANBindingDB-shows
5'-AMP-activated protein kinase catalytic subunit alpha-2AAPK2_HUMANBindingDB-shows
Activated CDC42 kinase 1ACK1_HUMANBindingDB-shows
Activin receptor type-1ACVR1_HUMANBindingDB-shows
Activin receptor type-1BACV1B_HUMANBindingDB-shows
Alpha-type platelet-derived growth factor receptorPGFRA_HUMANBindingDB-shows
B-Raf proto-oncogene serine/threonine-protein kinaseBRAF1_HUMANDrugBank-shows
Basic fibroblast growth factor receptor 1FGFR1_HUMANBindingDB-shows
Bcl2 antagonist of cell deathBAD_HUMANPROMISCUOUSPMID 16452220shows
Beta-type platelet-derived growth factor receptorPGFRB_HUMANDrugBank-shows
cAMP-dependent protein kinase catalytic subunit alphaKAPCA_HUMANBindingDB-shows
cAMP-dependent protein kinase catalytic subunit betaKAPCB_HUMANBindingDB-shows
Casein kinase I isoform gamma-2KC1G2_HUMANBindingDB-shows
Casein kinase II subunit alphaCSK21_HUMANBindingDB-shows
Cell division protein kinase 2CDK2_HUMANBindingDB-shows
Cell division protein kinase 5CDK5_HUMANBindingDB-shows
Cell division protein kinase 7CDK7_HUMANBindingDB-shows
Cell division protein kinase 8CDK8_HUMANBindingDB-shows
Cell division protein kinase 9CDK9_HUMANBindingDB-shows
Death-associated protein kinase 1DAPK1_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 1MP2K1_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 2MP2K2_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 4MP2K4_HUMANBindingDB-shows
Dual specificity protein kinase CLK1CLK1_HUMANBindingDB-shows
Ephrin type-A receptor 2EPHA2_HUMANBindingDB-shows
Ephrin type-B receptor 1EPHB1_HUMANBindingDB-shows
Epidermal growth factor receptorEGFR_HUMANBindingDB-shows
Epithelial discoidin domain-containing receptor 1DDR1_HUMANBindingDB-shows
Fibroblast growth factor receptor 2FGFR2_HUMANBindingDB-shows
Fibroblast growth factor receptor 3FGFR3_HUMANBindingDB-shows
Fibroblast growth factor receptor 4FGFR4_HUMANBindingDB-shows
FL cytokine receptorFLT3_HUMANDrugBank-shows
Focal adhesion kinase 1FAK1_HUMANBindingDB-shows
Glycogen synthase kinase-3 alphaGSK3A_HUMANBindingDB-shows
Glycogen synthase kinase-3 betaGSK3B_HUMANBindingDB-shows
Hepatocyte growth factor receptorMET_HUMANBindingDB-shows
High affinity nerve growth factor receptorNTRK1_HUMANBindingDB-shows
Inhibitor of nuclear factor kappa-B kinase subunit alphaIKKA_HUMANBindingDB-shows
Inhibitor of nuclear factor kappa-B kinase subunit betaIKKB_HUMANBindingDB-shows
Inhibitor of nuclear factor kappa-B kinase subunit epsilonIKKE_HUMANBindingDB-shows
Insulin receptorINSR_HUMANBindingDB-shows
Insulin-like growth factor 1 receptorIGF1R_HUMANBindingDB-shows
Macrophage colony-stimulating factor 1 receptorCSF1R_HUMANBindingDB-shows
MAP kinase-activated protein kinase 2MAPK2_HUMANBindingDB-shows
Mast/stem cell growth factor receptorKIT_HUMANDrugBank-shows
Mitogen-activated protein kinase 1MK01_HUMANBindingDB-shows
Mitogen-activated protein kinase 10MK10_HUMANBindingDB-shows
Mitogen-activated protein kinase 12MK12_HUMANBindingDB-shows
Mitogen-activated protein kinase 14MK14_HUMANBindingDB-shows
Mitogen-activated protein kinase 3MK03_HUMANBindingDB-shows
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPK3CA_HUMANBindingDB-shows
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoformPK3CB_HUMANBindingDB-shows
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoformPK3CD_HUMANBindingDB-shows
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoformPK3CG_HUMANBindingDB-shows
Protein kinase C alpha typeKPCA_HUMANBindingDB-shows
Protein kinase C epsilon typeKPCE_HUMANBindingDB-shows
Protein kinase C theta typeKPCT_HUMANBindingDB-shows
Protein tyrosine kinase 2 betaFAK2_HUMANBindingDB-shows
Proto-oncogene serine/threonine-protein kinase Pim-1PIM1_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase ABL1ABL1_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase FynFYN_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase LCKLCK_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase receptor retRET_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase SrcSRC_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase YesYES_HUMANBindingDB-shows
RAC-alpha serine/threonine-protein kinaseAKT1_HUMANBindingDB-shows
RAF proto-oncogene serine/threonine-protein kinaseRAF1_HUMANPROMISCUOUSPMID 16757355shows
RAF proto-oncogene serine/threonine-protein kinaseRAF1_MOUSEPROMISCUOUSPMID 15466206shows
Receptor tyrosine-protein kinase erbB-2ERBB2_HUMANBindingDB-shows
Receptor-interacting serine/threonine-protein kinase 1RIPK1_HUMANBindingDB-shows
Rho-associated protein kinase 1ROCK1_HUMANBindingDB-shows
Ribosomal protein S6 kinase alpha-5KS6A5_HUMANBindingDB-shows
Ribosomal protein S6 kinase beta-1KS6B1_HUMANBindingDB-shows
Serine/threonine-protein kinase 6STK6_HUMANBindingDB-shows
Serine/threonine-protein kinase D1KPCD1_HUMANBindingDB-shows
Serine/threonine-protein kinase PLK1PLK1_HUMANBindingDB-shows
Serine/threonine-protein kinase receptor R3ACVL1_HUMANBindingDB-shows
TGF-beta receptor type-2TGFR2_HUMANBindingDB-shows
Tubulin alpha-1A chainTBA1A_HUMANBindingDB-shows
Tyrosine-protein kinase ABL2ABL2_HUMANBindingDB-shows
Tyrosine-protein kinase BTKBTK_HUMANBindingDB-shows
Tyrosine-protein kinase CSKCSK_HUMANBindingDB-shows
Tyrosine-protein kinase HCKHCK_HUMANBindingDB-shows
Tyrosine-protein kinase ITK/TSKITK_HUMANBindingDB-shows
Tyrosine-protein kinase JAK2JAK2_HUMANBindingDB-shows
Tyrosine-protein kinase JAK3JAK3_HUMANBindingDB-shows
Tyrosine-protein kinase receptor TYRO3TYRO3_HUMANBindingDB-shows
Tyrosine-protein kinase SYKKSYK_HUMANBindingDB-shows
Tyrosine-protein kinase ZAP-70ZAP70_HUMANBindingDB-shows
Vascular endothelial growth factor receptor 1VGFR1_HUMANBindingDB-shows
Vascular endothelial growth factor receptor 2VGFR2_HUMANDrugBank-shows
Vascular endothelial growth factor receptor 3VGFR3_HUMANDrugBank-shows
Wee1-like protein kinaseWEE1_HUMANBindingDB-shows
Synonyms:
2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-
284461-73-0
4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide
4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate
4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE
BAX
BAY 43-9006
BAY 439006
BAY-43-0006
BAY-43-9006
BAY-54-9085
CHEBI:50924
DB00398
K00597a
LS-186067
LS-187021
LS-187788
N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyri
N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
NCGC00167488-01
nchembio.117-comp17
Nexavar
NSC-724772
Sorafenib
Sorafenib tosylate
Sorafenib [INN]
sorafenibum
STOCK6S-50043
ZINC01493878
ATC-Codes:
Side-Effects:
Side-EffectFrequency
weight loss0
influenza0
mediastinal disorders0
cholangitis0
heart disease0
hypothyroidism0
abdominal pain upper0
exfoliative dermatitis0
dyspepsia0
peripheral edema0
puncture0
breast disorders0
acute renal failure0
keratoacanthomas0
rash0
atopic dermatitis0
constipation0
folliculitis0
hematuria0
heart failure0
congestive heart failure0
stomatitis0
dry skin0
ulcer0
vascular disorders0
thrombocythemia0
infection0
gynecomastia0
amylase increased0
abdominal pain0
cerebral hemorrhage0
dyspnea0
vomiting0
neuropathy0
myalgia0
loss of consciousness0
arthralgia0
hypotension0
headache0
dehydration0
neutropenia0
connective tissue disorders0
erythema multiforme0
hematoma0
constitutional symptoms0
tachycardia0
pancreatitis0
proteinuria0
interstitial nephritis0
epistaxis0
thrombocytopenia0
hemorrhage0
mood alteration0
malaise0
gastritis0
dry mouth0
anemia0
jaundice0
dysphagia0
arrhythmia0
cancer0
gastroesophageal reflux0
gum hemorrhage0
pain0
pain in limb0
nausea0
transient ischemic attack0
urticaria0
erythema0
cholecystitis0
rectal hemorrhage0
esophageal varices0
fever0
acne0
hematemesis0
nephrotic syndrome0
hypertension0
lymphopenia0
pruritus0
syncope0
eczema0
renal failure0
hoarseness0
fatigue0
rhinorrhea0
endocrine disorders0
asthenia0
diarrhea0
tinnitus0
myocardial ischemia0
intracranial hemorrhage0
hemoptysis0
ascites0
dizziness0
edema0
menorrhagia0
anorexia0
hyponatremia0
hypophosphatemia0
pleural effusion0
flushing0
tumor0
leukopenia0
alopecia0
cough0
hypersensitivity0
glossodynia0