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Drug Details

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Name:Guanamprazine
PubChem ID:16231
Pathway:Show KEGG pathways
InChI:InChI=1/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)/f/h8-11H2
SMILES:c1(c(N)nc(c(Cl)n1)N)C(N=C(N)N)=O

Properties:
Formula:C6H8ClN7OAtoms:15
Molecular Weight:229.627Rotatable Bonds:2
H-bond Acceptors:8H-bond Donors:0
logP:1.271
Targets:
NameUniprot IDSourceReferencesInteraction
Adenosine receptor A2aAA2AR_HUMANBindingDB-shows
Alpha-2A adrenergic receptorADA2A_HUMANSuperTargetPMID 2843269shows
Amiloride-sensitive amine oxidase [copper-containing]ABP1_HUMANDrugBank-shows
Amiloride-sensitive cation channel 1, neuronalACCN1_HUMANDrugBank-shows
Amiloride-sensitive cation channel 2, neuronalACCN2_HUMANDrugBank-shows
Amiloride-sensitive cation channel 3ACCN3_HUMANBindingDB-shows
Amiloride-sensitive cation channel 4ACCN4_HUMANSuperTarget-shows
Amiloride-sensitive epithelial sodium channel alpha subunitQ6UP09_HUMANSuperTargetPMID 009575806shows
Amiloride-sensitive epithelial sodium channel gamma subunitQ6LCK5_HUMANSuperTargetPMID 009612219shows
Amiloride-sensitive sodium channel subunit alphaSCNNA_HUMANBindingDB-shows
Amiloride-sensitive sodium channel subunit betaSCNNB_HUMANDrugBank-shows
Amiloride-sensitive sodium channel subunit deltaSCNND_HUMANDrugBank-shows
Amiloride-sensitive sodium channel subunit gammaSCNNG_HUMANDrugBank-shows
ATP-binding cassette sub-family B member 8, mitochondrialABCB8_HUMANSuperTargetPMID 010187795shows
Atrial natriuretic factorANF_HUMANSuperTargetPMID 2571140shows
Beta-2 adrenergic receptorADRB2_HUMANSuperTargetPMID 2890352shows
Cationic trypsinTRY1_BOVINBindingDB-shows
cDNA FLJ16802 fis, clone TESTI4005158, highly similar to Amiloride-sensitive sodium channel delta-subunitQ6ZMN3_HUMANSuperTargetPMID 009570944shows
cDNA FLJ37317 fis, clone BRAMY2017455, highly similar to Homo sapiens ATP-binding cassette protein M-ABC1 mRNAQ8N1X3_HUMANSuperTargetPMID 010187795shows
Cytochrome P450 1A1CP1A1_HUMANSuperCypPMID 15081870shows
Epithelial sodium channel beta-2 subunitQ8WY57_HUMANSuperTargetPMID 008640238shows
Na+/H+ exchanger isoform NHE-2O00618_HUMANSuperTargetPMID 008244989shows
Na+/H+ exchanger isoform NHE-3O00617_HUMANSuperTargetPMID 008415663shows
Plasminogen activator, urokinaseQ53XS3_HUMANSuperTargetPMID 010738907shows
Plasminogen activator, urokinaseQ5SWW8_HUMANSuperTargetPMID 010738907shows
PLAU proteinQ9UEJ5_HUMANSuperTargetPMID 010738907shows
Sodium/hydrogen exchanger 1SL9A1_HUMANBindingDB-shows
Sodium/hydrogen exchanger 2SL9A2_HUMANSuperTargetPMID 008244989shows
Sodium/hydrogen exchanger 3SL9A3_HUMANSuperTargetPMID 008415663shows
Tissue-type plasminogen activatorTPA_HUMANBindingDB-shows
Urokinase plasminogen activatorQ5PY49_HUMANSuperTargetPMID 010738907shows
Urokinase plasminogen activator preproprotein variantQ59GZ8_HUMANSuperTargetPMID 010738907shows
Urokinase-type plasminogen activatorUROK_HUMANBindingDB-shows
Urokinase-type plasminogen activator amino-terminalQ96SE8_HUMANSuperTargetPMID 010738907shows
Synonyms:
17440-83-4
1f5l
2016-88-8
2016-88-8 (HYDROCHLORIDE);17440-83-4 (HYDROCHLORIDE DIHYDRATE)
2609-46-3
3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide
3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide
3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide
AB00053415
AIDS-057138
AIDS057138
Amiclaran
Amiclaran (TN)
Amikal (Hydrochloride dihydrate)
Amilorida
Amilorida [INN-Spanish]
Amiloride
Amiloride (INN)
AMILORIDE (SEE ALSO: AMILORIDE HCL (2016-88-8))
Amiloride HCL
Amiloride hydrochloride
Amiloride hydrochloride hydrate
Amiloride [INN:BAN]
Amiloridum
Amiloridum [INN-Latin]
Amipramidin
Amipramizid
Amipramizide
Amiprazidine
AMR
Amyloride
BCBcMAP01_000101
Bio1_000359
Bio1_000848
Bio1_001337
Bio2_000292
Bio2_000772
BPBio1_000015
BSPBio_000013
BSPBio_001572
BSPBio_001826
C06821
C6H8ClN7O
CCRIS 6545
CHEBI:2639
CPD-10324
D07447
DB00594
DivK1c_000182
EINECS 220-024-7
Guanamprazin
Guanamprazine
IDI1_000182
IDI1_034042
KBio1_000182
KBio2_000292
KBio2_000394
KBio2_002860
KBio2_002962
KBio2_005428
KBio2_005530
KBio3_000583
KBio3_000584
KBio3_001326
KBioGR_000292
KBioGR_000544
KBioSS_000292
KBioSS_000394
Lopac-A-7410
Lopac0_000111
LS-1094
Midamor
Midamor (Hydrochloride dihydrate)
MK-870 (Hydrochloride dihydrate)
MLS000758249
MLS001060798
N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide
N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid
NCGC00015089-01
NCGC00015089-02
NCGC00024443-02
NCGC00024443-05
NCGC00024443-06
NCGC00024443-07
NCGC00024443-09
NINDS_000182
Prestwick0_000007
Prestwick1_000007
Prestwick2_000007
Prestwick3_000007
Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-
Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-,
Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride
SMR000449325
SMR000486264
SPBio_000136
SPBio_001934
Spectrum2_000118
Spectrum3_000293
Spectrum4_000132
Spectrum5_000776
Spectrum_000034
ST079279
Tocris-0890
ZINC04340269
ATC-Codes:
Side-Effects:
Side-EffectFrequency
neutropenia0.0010
confusion0.0010
tremors0.0010
jaundice0.0010
liver disease0.0010
aplastic anemia0.0010
peptic ulcer0.0010
hepatic encephalopathy0.0010
coma0.0010
pruritus0
pulmonary edema0
purpura0
renal failure0
shock0
sialadenitis0
spasm0
polyuria0
pneumonia0
numbness0
nocturia0
pain0
palpitations0
bradycardia0
pancreatitis0
weakness0
paresthesia0
heartburn0
stevens - johnson syndrome0
syncope0
complete heart block0
muscle weakness0
malaise0
blurred vision0
shortness of breath0
paralysis0
urinary frequency0
increased sweating0
hyperuricemia0
agitation0
stupor0
encephalopathy0
tachycardia0
thrombocytopenia0
tinnitus0
urinary incontinence0
urticaria0
vasculitis0
vertigo0
vomiting0
dry mouth0
insomnia0
nervousness0
abdominal pain0
dehydration0
exfoliative dermatitis0
diarrhea0
dizziness0
somnolence0
dyspepsia0
dyspnea0
dysuria0
toxic epidermal necrolysis0
decreased libido0
cough0
alopecia0
anaphylaxis0
hemolytic anemia0
angina pectoris0
anorexia0
arthralgia0
back pain0
chest pain0
constipation0
erythema multiforme0
rash0
hyperglycemia0
hypersensitivity0
hyponatremia0
postural hypotension0
impotence0
leukopenia0
muscle cramps0
nasal congestion0
nausea0
hiccup0
heart block0
fatigue0
fever0
flatulence0
flushing0
gastrointestinal hemorrhage0
glycosuria0
gout0
gynecomastia0
headache0
interstitial nephritis0