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Name:Roscovitine
PubChem ID:160355
Pathway:Show KEGG pathways
InChI:InChI=1/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1/f/h20,22H
SMILES:CC[C@@H](CO)Nc1nc(c2c(n1)n(cn2)C(C)C)NCc1ccccc1

Properties:
Formula:C19H26N6OAtoms:27
Molecular Weight:354.449Rotatable Bonds:8
H-bond Acceptors:6H-bond Donors:0
logP:3.3481
Targets:
NameUniprot IDSourceReferencesInteraction
3-phosphoinositide-dependent protein kinase 1PDPK1_HUMANBindingDB-shows
5'-AMP-activated protein kinase catalytic subunit alpha-1AAPK1_HUMANBindingDB-shows
5'-AMP-activated protein kinase catalytic subunit alpha-2AAPK2_HUMANBindingDB-shows
Activated CDC42 kinase 1ACK1_HUMANBindingDB-shows
Activin receptor type-1ACVR1_HUMANBindingDB-shows
Activin receptor type-1BACV1B_HUMANBindingDB-shows
Alpha-type platelet-derived growth factor receptorPGFRA_HUMANBindingDB-shows
Basic fibroblast growth factor receptor 1FGFR1_HUMANBindingDB-shows
Beta-type platelet-derived growth factor receptorPGFRB_HUMANBindingDB-shows
cAMP-dependent protein kinase catalytic subunit alphaKAPCA_HUMANBindingDB-shows
cAMP-dependent protein kinase catalytic subunit betaKAPCB_HUMANBindingDB-shows
Casein kinase I isoform gamma-2KC1G2_HUMANBindingDB-shows
Casein kinase II subunit alphaCSK21_HUMANBindingDB-shows
CaspaseICE_DROMEPROMISCUOUSPMID 10871858shows
Cell division protein kinase 2CDK2_HUMANBindingDB-shows
Cell division protein kinase 4CDK4_HUMANBindingDB-shows
Cell division protein kinase 5CDK5_HUMANBindingDB-shows
Cell division protein kinase 7CDK7_HUMANBindingDB-shows
Cell division protein kinase 8CDK8_HUMANBindingDB-shows
Cell division protein kinase 9CDK9_HUMANBindingDB-shows
Cyclin-A2CCNA2_HUMANBindingDB-shows
Death-associated protein kinase 1DAPK1_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 1MP2K1_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 2MP2K2_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 4MP2K4_HUMANBindingDB-shows
Dual specificity protein kinase CLK1CLK1_HUMANBindingDB-shows
Ephrin type-A receptor 2EPHA2_HUMANBindingDB-shows
Ephrin type-B receptor 1EPHB1_HUMANBindingDB-shows
Epidermal growth factor receptorEGFR_HUMANBindingDB-shows
Epithelial discoidin domain-containing receptor 1DDR1_HUMANBindingDB-shows
Fibroblast growth factor receptor 2FGFR2_HUMANBindingDB-shows
Fibroblast growth factor receptor 3FGFR3_HUMANBindingDB-shows
Fibroblast growth factor receptor 4FGFR4_HUMANBindingDB-shows
FL cytokine receptorFLT3_HUMANBindingDB-shows
Focal adhesion kinase 1FAK1_HUMANBindingDB-shows
Focal adhesion kinase 1FAK1_MOUSEPROMISCUOUSPMID 18042622shows
Geranylgeranyl pyrophosphate synthetaseGGPPS_HUMANPROMISCUOUSPMID 10871858shows
Glycogen synthase kinase-3 alphaGSK3A_HUMANBindingDB-shows
Glycogen synthase kinase-3 betaGSK3B_HUMANBindingDB-shows
Hepatocyte growth factor receptorMET_HUMANBindingDB-shows
High affinity nerve growth factor receptorNTRK1_HUMANBindingDB-shows
Inhibitor of nuclear factor kappa-B kinase subunit epsilonIKKE_HUMANBindingDB-shows
Insulin receptorINSR_HUMANBindingDB-shows
Insulin-like growth factor 1 receptorIGF1R_HUMANBindingDB-shows
Macrophage colony-stimulating factor 1 receptorCSF1R_HUMANBindingDB-shows
MAP kinase-activated protein kinase 2MAPK2_HUMANBindingDB-shows
Mast/stem cell growth factor receptorKIT_HUMANBindingDB-shows
Mdm2A7UKX7_HUMANPROMISCUOUSPMID 11423970shows
Mdm2A7UKX8_HUMANPROMISCUOUSPMID 11423970shows
Mdm2A7UKX9_HUMANPROMISCUOUSPMID 11423970shows
Mdm2A7UKY0_HUMANPROMISCUOUSPMID 11423970shows
Mitogen-activated protein kinase 1MK01_HUMANBindingDB-shows
Mitogen-activated protein kinase 1Q1HBJ4_HUMANPROMISCUOUSPMID 9030781shows
Mitogen-activated protein kinase 1Q499G7_HUMANPROMISCUOUSPMID 9030781shows
Mitogen-activated protein kinase 10MK10_HUMANBindingDB-shows
Mitogen-activated protein kinase 12MK12_HUMANBindingDB-shows
Mitogen-activated protein kinase 14MK14_HUMANBindingDB-shows
Mitogen-activated protein kinase 3MK03_HUMANBindingDB-shows
Mitogen-activated protein kinase 3B0LPG3_HUMANPROMISCUOUSPMID 9030781shows
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPK3CA_HUMANBindingDB-shows
Prostaglandin G/H synthase 2PGH2_BOVINPROMISCUOUSPMID 12658640shows
Protein kinaseQ60647_MOUSEPROMISCUOUSPMID 10727255shows
Protein kinaseQ64493_MOUSEPROMISCUOUSPMID 10727255shows
Protein kinaseQ64736_MOUSEPROMISCUOUSPMID 10727255shows
Protein kinaseQ78E06_MOUSEPROMISCUOUSPMID 10727255shows
Protein kinase C epsilon typeKPCE_HUMANBindingDB-shows
Protein kinase C theta typeKPCT_HUMANBindingDB-shows
Protein tyrosine kinase 2 betaFAK2_HUMANBindingDB-shows
Proto-oncogene serine/threonine-protein kinase Pim-1PIM1_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase ABL1ABL1_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase FynFYN_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase LCKLCK_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase receptor retRET_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase SrcSRC_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase YesYES_HUMANBindingDB-shows
Pyridoxal kinasePDXK_MOUSEPROMISCUOUSPMID 15975926shows
RAC-alpha serine/threonine-protein kinaseAKT1_HUMANBindingDB-shows
Receptor tyrosine-protein kinase erbB-2ERBB2_HUMANBindingDB-shows
Receptor-interacting serine/threonine-protein kinase 1RIPK1_HUMANBindingDB-shows
Regulator of G-protein signaling 2RGS2_HUMANPROMISCUOUSPMID 16733081shows
Ribosomal protein S6 kinase alpha-5KS6A5_HUMANBindingDB-shows
Serine/threonine-protein kinase 6STK6_HUMANBindingDB-shows
Serine/threonine-protein kinase D1KPCD1_HUMANBindingDB-shows
Serine/threonine-protein kinase PLK1PLK1_HUMANBindingDB-shows
Serine/threonine-protein kinase receptor R3ACVL1_HUMANBindingDB-shows
TGF-beta receptor type-2TGFR2_HUMANBindingDB-shows
Tubulin alpha-1A chainTBA1A_HUMANBindingDB-shows
Tyrosine-protein kinase ABL2ABL2_HUMANBindingDB-shows
Tyrosine-protein kinase BTKBTK_HUMANBindingDB-shows
Tyrosine-protein kinase CSKCSK_HUMANBindingDB-shows
Tyrosine-protein kinase HCKHCK_HUMANBindingDB-shows
Tyrosine-protein kinase ITK/TSKITK_HUMANBindingDB-shows
Tyrosine-protein kinase JAK2JAK2_HUMANBindingDB-shows
Tyrosine-protein kinase JAK3JAK3_HUMANBindingDB-shows
Tyrosine-protein kinase receptor TYRO3TYRO3_HUMANBindingDB-shows
Tyrosine-protein kinase SYKKSYK_HUMANBindingDB-shows
Tyrosine-protein kinase ZAP-70ZAP70_HUMANBindingDB-shows
Vascular endothelial growth factor receptor 1VGFR1_HUMANBindingDB-shows
Vascular endothelial growth factor receptor 2VGFR2_HUMANBindingDB-shows
Vascular endothelial growth factor receptor 3VGFR3_HUMANBindingDB-shows
Wee1-like protein kinaseWEE1_HUMANBindingDB-shows
Synonyms:
"insolution™ roscovitine"
(2r)-2-{[6-(benzylamino)-9-isopropyl-9h-purin-2-yl]amino}-1-butanol
(R)-Roscovitine
1-Butanol,
1-Butanol, 2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2- yl)amino)-, (2R)-
1-Butanol, 2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2- yl)amino)-, (2R)-
1-Butanol, 2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2- yl)amino)-, (R)-
1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-
186692-46-6
2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine
2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol
2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]- 9H-purin-2-yl]amino]-(R)-1-butanol
2a4l
3ddq
6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
AIDS-022527
AIDS022527
BCBcMAP01_000013
Bio1_000302
Bio1_000791
Bio1_001280
Bio2_000379
Bio2_000859
BiomolKI2_000054
BiomolKI_000048
BSPBio_001078
CBiol_002016
CYC 202
CYC-202
CYC202
CYC202, Seliciclib, R-roscovitine, Roscovitine
HSCI1_000092
IDI1_002134
InSolution™ Roscovitine
K00020
KBio2_000418
KBio2_002986
KBio2_005554
KBio3_000795
KBio3_000796
KBioGR_000418
KBioSS_000418
Lopac0_001102
LS-182554
NCGC00094374-01
NCGC00094374-02
NCGC00094374-03
NCGC00094374-04
NCI60_036420
NSC 701554
NSC-701554
NSC701554
R-Roscovitine
R7772_SIGMA
Rosco
Roscovitine
RRC
Seliciclib
SMP1_000266
ZINC01649340