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Name:Gefitinib
PubChem ID:123631
Pathway:Show KEGG pathways
InChI:InChI=1/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)/f/h27H
SMILES:COc1cc2c(cc1OCCCN1CCOCC1)c(ncn2)Nc1ccc(c(c1)Cl)F

Properties:
Formula:C22H24ClFN4O3Atoms:31
Molecular Weight:446.902Rotatable Bonds:8
H-bond Acceptors:8H-bond Donors:0
logP:4.2865
Targets:
NameUniprot IDSourceReferencesInteraction
3-phosphoinositide-dependent protein kinase 1PDPK1_HUMANBindingDB-shows
5'-AMP-activated protein kinase catalytic subunit alpha-1AAPK1_HUMANBindingDB-shows
5'-AMP-activated protein kinase catalytic subunit alpha-2AAPK2_HUMANBindingDB-shows
Activated CDC42 kinase 1ACK1_HUMANBindingDB-shows
Activin receptor type-1ACVR1_HUMANBindingDB-shows
Activin receptor type-1BACV1B_HUMANBindingDB-shows
Alpha-type platelet-derived growth factor receptorPGFRA_HUMANBindingDB-shows
ATP-binding cassette sub-family G member 2ABCG2_HUMANBindingDB-shows
Baculoviral IAP repeat-containing protein 4XIAP_HUMANPROMISCUOUSPMID 17308080shows
Basic fibroblast growth factor receptor 1FGFR1_HUMANBindingDB-shows
Beta-type platelet-derived growth factor receptorPGFRB_HUMANBindingDB-shows
Breast cancer resistance proteinQ8WZ76_HUMANSuperTargetPMID 015753373shows
cAMP-dependent protein kinase catalytic subunit alphaKAPCA_HUMANBindingDB-shows
cAMP-dependent protein kinase catalytic subunit betaKAPCB_HUMANBindingDB-shows
Casein kinase I isoform gamma-2KC1G2_HUMANBindingDB-shows
Casein kinase II subunit alphaCSK21_HUMANBindingDB-shows
Cell division protein kinase 2CDK2_HUMANBindingDB-shows
Cell division protein kinase 5CDK5_HUMANBindingDB-shows
Cell division protein kinase 7CDK7_HUMANBindingDB-shows
Cell division protein kinase 8CDK8_HUMANBindingDB-shows
Cell division protein kinase 9CDK9_HUMANBindingDB-shows
CruzipainCYSP_TRYCRBindingDB-shows
Cytochrome P450 2C19CP2CJ_HUMANSuperCyp-shows
Cytochrome P450 2D6CP2D6_HUMANSuperCypPMID 15788367shows
Cytochrome P450 3A4CP3A4_HUMANSuperCypPMID 14977817shows
Death-associated protein kinase 1DAPK1_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 1MP2K1_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 2MP2K2_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 4MP2K4_HUMANBindingDB-shows
Dual specificity protein kinase CLK1CLK1_HUMANBindingDB-shows
Ephrin type-A receptor 2EPHA2_HUMANBindingDB-shows
Ephrin type-B receptor 1EPHB1_HUMANBindingDB-shows
Epidermal growth factor receptorEGFR_HUMANBindingDB-shows
Epidermal growth factor receptorQ4H1F3_HUMANSuperTargetPMID 015610717shows
Epidermal growth factor receptorQ68GS6_HUMANSuperTargetPMID 015610717shows
Epidermal growth factor receptorQ8WZA5_HUMANSuperTargetPMID 015610717shows
Epidermal growth factor receptor isoform a variantQ59FL8_HUMANSuperTargetPMID 015610717shows
Epithelial discoidin domain-containing receptor 1DDR1_HUMANBindingDB-shows
Fibroblast growth factor receptor 2FGFR2_HUMANBindingDB-shows
Fibroblast growth factor receptor 3FGFR3_HUMANBindingDB-shows
Fibroblast growth factor receptor 4FGFR4_HUMANBindingDB-shows
FL cytokine receptorFLT3_HUMANBindingDB-shows
Focal adhesion kinase 1FAK1_HUMANBindingDB-shows
Glycogen synthase kinase-3 alphaGSK3A_HUMANBindingDB-shows
Glycogen synthase kinase-3 betaGSK3B_HUMANBindingDB-shows
Hepatocyte growth factor receptorMET_HUMANBindingDB-shows
High affinity nerve growth factor receptorNTRK1_HUMANBindingDB-shows
Inhibitor of nuclear factor kappa-B kinase subunit epsilonIKKE_HUMANBindingDB-shows
Insulin receptorINSR_HUMANBindingDB-shows
Insulin-like growth factor 1 receptorIGF1R_HUMANBindingDB-shows
Macrophage colony-stimulating factor 1 receptorCSF1R_HUMANBindingDB-shows
MAP kinase-activated protein kinase 2MAPK2_HUMANBindingDB-shows
Mast/stem cell growth factor receptorKIT_HUMANBindingDB-shows
Mitogen-activated protein kinase 1MK01_HUMANBindingDB-shows
Mitogen-activated protein kinase 10MK10_HUMANBindingDB-shows
Mitogen-activated protein kinase 12MK12_HUMANBindingDB-shows
Mitogen-activated protein kinase 14MK14_HUMANBindingDB-shows
Mitogen-activated protein kinase 3MK03_HUMANBindingDB-shows
Phosphatidylinositol 3-kinase catalytic subunit type 3PK3C3_HUMANPROMISCUOUSPMID 11585753shows
Phosphatidylinositol 3-kinase catalytic subunit type 3PK3C3_MOUSEPROMISCUOUSPMID 18568074shows
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPK3CA_HUMANBindingDB-shows
Prostate-specific antigenKLK3_HUMANPROMISCUOUSPMID 15833875shows
Protein kinase C epsilon typeKPCE_HUMANBindingDB-shows
Protein kinase C theta typeKPCT_HUMANBindingDB-shows
Protein tyrosine kinase 2 betaFAK2_HUMANBindingDB-shows
Proto-oncogene serine/threonine-protein kinase Pim-1PIM1_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase ABL1ABL1_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase FynFYN_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase LCKLCK_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase receptor retRET_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase SrcSRC_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase YesYES_HUMANBindingDB-shows
Putative HERV-K_Xq28 provirus ancestral Pol proteinPOKL_HUMANPROMISCUOUSPMID 17094457shows
Putative uncharacterized protein ABCG2Q4W5I3_HUMANSuperTargetPMID 015753373shows
Putative uncharacterized protein EGFRQ75MF2_HUMANSuperTargetPMID 015610717shows
RAC-alpha serine/threonine-protein kinaseAKT1_HUMANBindingDB-shows
Rad51Q6TAR4_HUMANPROMISCUOUSPMID 18377894shows
RAD51Q9NZG9_HUMANPROMISCUOUSPMID 18377894shows
Receptor tyrosine-protein kinase erbB-2ERBB2_HUMANBindingDB-shows
Receptor-interacting serine/threonine-protein kinase 1RIPK1_HUMANBindingDB-shows
Ribosomal protein S6 kinase alpha-5KS6A5_HUMANBindingDB-shows
Serine/threonine-protein kinase 6STK6_HUMANBindingDB-shows
Serine/threonine-protein kinase D1KPCD1_HUMANBindingDB-shows
Serine/threonine-protein kinase PLK1PLK1_HUMANBindingDB-shows
Serine/threonine-protein kinase receptor R3ACVL1_HUMANBindingDB-shows
Telomerase reverse transcriptaseTERT_HUMANPROMISCUOUSPMID 17094457shows
TGF-beta receptor type-2TGFR2_HUMANBindingDB-shows
Truncated epidermal growth factor receptorQ9H3C8_HUMANSuperTargetPMID 015610717shows
Tubulin alpha-1A chainTBA1A_HUMANBindingDB-shows
Tyrosine-protein kinase ABL2ABL2_HUMANBindingDB-shows
Tyrosine-protein kinase BTKBTK_HUMANBindingDB-shows
Tyrosine-protein kinase CSKCSK_HUMANBindingDB-shows
Tyrosine-protein kinase HCKHCK_HUMANBindingDB-shows
Tyrosine-protein kinase ITK/TSKITK_HUMANBindingDB-shows
Tyrosine-protein kinase JAK2JAK2_HUMANBindingDB-shows
Tyrosine-protein kinase JAK3JAK3_HUMANBindingDB-shows
Tyrosine-protein kinase receptor TYRO3TYRO3_HUMANBindingDB-shows
Tyrosine-protein kinase SYKKSYK_HUMANBindingDB-shows
Tyrosine-protein kinase ZAP-70ZAP70_HUMANBindingDB-shows
Vascular endothelial growth factor receptor 1VGFR1_HUMANBindingDB-shows
Vascular endothelial growth factor receptor 2VGFR2_HUMANBindingDB-shows
Vascular endothelial growth factor receptor 3VGFR3_HUMANBindingDB-shows
Wee1-like protein kinaseWEE1_HUMANBindingDB-shows
Synonyms:
"gefitini; iressa"
184475-35-2
4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazolin
4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline
4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-
4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-4-morpholin)propoxy)-
6-(3-morpholinopropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine
BCB03_000781
C419708
CCRIS 9011
CHEBI:49668
CU-00000000396-1
D01977
DB00317
Gefitini; Iressa
Gefitinib
Gefitinib (JAN/USAN/INN)
Gefitinib [USAN]
IRE
Iressa
Iressa (TN)
Irressat
K00240
KBioSS_002241
LS-139916
N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamide
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamine
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine
NCGC00159455-02
NCGC00159455-03
nchembio.117-comp18
nchembio866-comp14
NSC715055
STOCK6S-52331
ZD 1839
ZD-1839
ZD-1839, Iressa, Gefitinib
ZD1839
ZINC19632614
ATC-Codes:
Side-Effects:
Side-EffectFrequency
rash0.21499999
diarrhea0.19199999
acne0.125
dry skin0.065
nausea0.051999997
vomiting0.048
pruritus0.04
anorexia0.035
asthenia0.03
interstitial lung disease0.0010
toxic epidermal necrolysis0.0010
allergic reactions0.0010
eye pain0.0010
idiopathic pulmonary fibrosis0.0010
ulcer0.0010
interstitial pneumonia0.0010
pneumonitis0.0010
pancreatitis0.0010
cough0.0010
dyspnea0.0010
epistaxis0.0010
erythema multiforme0.0010
angioedema and urticaria0.0010
fever0.0010
hematuria0.0010
haemorrhage0.0010
ischemia0.0010
deep thrombophlebitis0
bundle branch block0
dry eyes0
mouth ulceration0
gastrointestinal hemorrhage0
peripheral edema0
exfoliative dermatitis0
dermatitis0
hypotension0
constitutional symptoms0
hemoptysis0
electrolyte imbalance0
tumor0
melena0
infection0
shock0
pleural effusion0
hypokalemia0
fatigue0
respiratory failure0
heart disease0
hypoxia0
conjunctivitis0
arrhythmia0
hypomagnesemia0
mediastinal disorders0
stevens - johnson syndrome0
thrombocytopenia0
stomatitis0
amblyopia0
sgot increased0
seborrhea0
constipation0
paronychia0
alopecia0
pain0
neutropenia0
nail disorder0
anemia0
dry mouth0
blepharitis0
urticaria0
abdominal pain0
dehydration0
atrial fibrillation0
pneumoconiosis0
edema0
vascular disorders0
weight loss0