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Name:Bosentan
PubChem ID:104865
Pathway:Show KEGG pathways
InChI:InChI=1/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32)/f/h32H
SMILES:CC(C)(C)c1ccc(cc1)S(Nc1c(c(nc(c2ncccn2)n1)OCCO)Oc1ccccc1OC)(=O)=O

Properties:
Formula:C27H29N5O6SAtoms:39
Molecular Weight:551.614Rotatable Bonds:11
H-bond Acceptors:11H-bond Donors:0
logP:5.3577
Targets:
Synonyms:
147536-97-8
174227-18-0
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide
4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)(2,2'-bipyrimidin)-4-yl)-
Bosentan
Bosentan (INN)
Bosentan hydrate
Bosentan [USAN:INN:BAN]
C27H29N5O6S
CHEBI:51450
D07538
DB00559
LS-31532
NCGC00167440-01
p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)
p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
PDSP1_001731
PDSP2_001714
Ro 47-0203
Ro 47-0203/039
Ro-47-0203
Ro-47-0203/029
Ro-47-0203/039
TL8001039
Tracleer
ATC-Codes:
Side-Effects:
Side-EffectFrequency
headache0.13239999
nasopharyngitis0.10999999
palpitations0.05
edema0.04525
hypotension0.042400002
fatigue0.04
dyspepsia0.04
flushing0.039142855
pruritus0.0244
hepatic cirrhosis0.0010
pain0.0010
peripheral edema0.0010
liver failure0.0010
weight gain0.0010
thrombocytopenia0.0010
pulmonary edema0.0010
infections0.0010
postural hypotension0.0010
anaphylaxis0.0010
anemia0.0010
angioneurotic edema0.0010
dermatitis0.0010
dizziness0.0010
rash0.0010
pyrexia0.0010
heart failure0.0010
hemorrhage0.0010
hypersensitivity0.0010
hypertension0.0010
lactic dehydrogenase increased0
tachycardia0
subarachnoid hemorrhage0
abdominal pain upper0
ischemia0
lower respiratory infection0
musculoskeletal pain0
ecchymosis0
anorexia0
muscle cramps0
restless legs syndrome0
heart disease0
cardiac arrest0
photophobia0
paresthesia0
bronchospasm0
hematuria0
acute bronchitis0
dry skin0
vascular disorders0
influenza0
complete heart block0
mediastinal disorders0
urinary frequency0
somnolence0
erythema multiforme0
respiratory failure0
vomiting0
anxiety0
hydrocephalus0
arthralgia0
upper respiratory tract infection0
increased sweating0
dysuria0
disturbance in attention0
agitation0
emotional lability0
insomnia0
angina pectoris0
epistaxis0
als0
nasal congestion0
toothache0
hepatitis0
latent diabetes0
wheezing0
dehydration0
abdominal distention0
abdominal pain0
dyspnea0
irritability0
erythema0
pain in limb0
nausea0
syncope0
eczema0
conjunctivitis0
bradycardia0
atrial fibrillation0
duodenal ulcer0
hypokalemia0
ascites0
chest pain0
gastroenteritis0
arrhythmia0
back pain0
rectal hemorrhage0
myocardial infarction0
nightmares0
urinary tract infection0
stevens - johnson syndrome0
urticaria0
renal failure0
dry mouth0
jaundice0
cerebrovascular accident0
pneumonia0
sinusitis0
diarrhea0
tinnitus0
bronchitis0
mouth ulceration0
hemoptysis0
tremor0
hemiparesis0
cystitis0
gout0
constipation0
vertigo0
asthma0
ventricular tachycardia0
blurred vision0
cough0
flatulence0
skin ulcer0
nephropathy0
panic attacks0
alkaline phosphatase increased0
hyperglycemia0
hyponatremia0
hypoglycemia0
weakness0